Speed up the transport of fat This protein can help the liver "lose weight"

Original title: Speed up the removal of fat This protein can help the liver "lose weight"
people's liver, there is a "fat porter" - very low density lipoprotein. It "transports" fat from the liver and secretes it into the bloodstream, reducing the accumulation of fat in the liver, thereby reducing the probability of fatty liver disease. Recently, a study by Professor Li Zhong of Nanjing Medical University's School of Basic Medicine found that there is a protein in liver cells that assumes the function of fat secretion "accelerator" - PNPLA7, which can promote the secretion of very low density lipoprotein in the liver and reduce the accumulation of fat in the liver, the results of which were published in the international journal Hemology.
, non-alcoholic fatty liver disease caused by overnutrition has become a global epidemic. How to effectively prevent and treat such diseases has become a global challenge.
Zhong, a professor at Nanjing Medical University's School of Basic Medicine, found a positive correlation between expression levels of PNPLA7 protein and blood lipid levels in population studies. They studied mice with missing "accelerator" proteins in liver cells and fed them high-fat feed, characterized by severe fatty liver disease but significantly lower blood lipid levels.
researchers confirmed that the secretion of very low-density lipoproteins in mice was significantly inhibited by the absence of PNPLA7 protein, leading to lipid build-up in the liver and lower blood lipid levels.
even more significant is that the expression of "accelerator" proteins in liver cells can significantly promote the secretion of very low-density lipoproteins and reduce the accumulation of fat in liver cells.
"Our study is the first to find that the PNPLA7 protein promotes the production of very low-density lipoproteins in the liver, which acts like an 'accelerator' in the process of fat secretion in the liver. Although unknown in the daily state, but when the body is in a fatty liver or hungry state, it is high expression, promote the secretion of very low density lipoprotein, the lipids from the liver transported out, maintain the liver lipid metabolic balance. Li Zhong said the study provides new targets and basis for the prevention and treatment of fatty liver disease, hyperlipidemia and related metabolic diseases.
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