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    Home > Biochemistry News > Biotechnology News > SPR Biosensor as a Tool for Screening Prion Protein Binders as Potential Antiprion Leads

    SPR Biosensor as a Tool for Screening Prion Protein Binders as Potential Antiprion Leads

    • Last Update: 2020-12-06
    • Source: Internet
    • Author: User
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    Prion diseases, also called transmissible spongiform encephalopathies (TSEs), are a group of neurodegenerative disorders affecting animals and humans. No effective treatments are currently available for the diseases, vCJD in particular. It is believed that the formation of protease-resistant insoluble prion protein (PrP
    Sc
    ), which is the main component of amyloidal deposits, from the cellular prion protein (PrP
    C
    ), is essential for the progression of the disease. Therefore, both PrP
    Sc
    and PrP
    C
    are currently being used as potential drug targets.This protocol details an optimised experimental protocol to conduct an affinity screening of compound libraries by the immobilisation of PrP
    C
    using an SPR-based instrument, Biacore 3000.
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