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    Home > Biochemistry News > Biotechnology News > Staphylococcal Bap protein forms functional amyloid fibers through phase transition and mediates the regulation mechanism of biofilm formation

    Staphylococcal Bap protein forms functional amyloid fibers through phase transition and mediates the regulation mechanism of biofilm formation

    • Last Update: 2021-08-10
    • Source: Internet
    • Author: User
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    In recent years, nosocomial infections caused by multi-drug resistant Staphylococcus aureus have posed a great threat to human health


    On May 28, 2021, Fang Xianyang's research group from the School of Life Sciences, Tsinghua University published in The EMBO Journal the title "Structural mechanism for staphylococcal biofilm-related protein switches to regulate the formation of functional amyloid fibers and biofilms.


    Figure 1.


    The research has the following important findings:

    1) The N-terminus of BSP contains repeating series of structural modules, which can be used as scaffold proteins to mediate liquid-liquid-liquid separation and aggregate into amyloid fibers through liquid-solid phase transformation


    2) As a novel calcium-binding motif, the middle module of BSP has a completely different structure from a variety of calcium-binding motifs discovered in eukaryotes and prokaryotes in recent years


    3) Under the conditions of low pH and low calcium ion concentration, the various structural modules of BSP coordinate the formation of amyloid fibers and mediate the formation of Staphylococcus aureus biofilm


    Assistant Professor Fang Xianyang, School of Life Sciences, Tsinghua University, is the corresponding author of the article, 2016 doctoral student Ma Junfeng is the first author of the article, research assistant Cheng Xiang, 2017 doctoral student Xu Zhonghe, and graduated doctoral student Zhang Yikan made this topic Important contribution


    Original link: https://

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