Staying up late will "be stupid". During sleep, the brain will start a "detoxification" program to clear the brain...

With the increasing global aging, people are no longer unfamiliar with Alzheimer's disease (AD)

For a long time, research on Alzheimer’s disease has focused on how to empty the two key proteins "amyloid beta" and "tau protein".

In 2015, a heavyweight study published in the top academic journal "Nature" overturned traditional cognition

Recently, researchers from the University of Pennsylvania published an article titled Reduced coupling between cerebrospinal fluid flow and global brain activity is linked to Alzheimer disease-related pathology in PLOS Biology.

In this latest study, researchers used 118 subjects in the Alzheimer's Disease Neuroimaging Initiative (ADNI) to monitor whole brain activity and cerebrospinal fluid flow, and view their Behavioral data

At the same time, the subjects received resting state functional magnetic resonance imaging (fMRI) every two years, and then the data results were correlated with the neurobiological and neuropsychological markers "toxic β-starch" related to Alzheimer's disease.

Participant baseline characteristics

The study has discovered a potential marker that can be used to clinically assess the risk of Alzheimer's disease through non-invasive imaging tests

This shows that sleep-dependent global brain activity plays an important role in removing brain waste, and its connection with cerebrospinal fluid flow may be a potential standard for future clinical evaluation

The global blood oxygen level depends on the coupling between the signal and the cerebrospinal fluid signal

The author of the study, Dr.

In fact, the "detoxification" effect of sleep on the brain has been continuously revealed

The article pointed out that more and more studies have shown that sleep can activate the lymphoid system to "clean up" the brain.

Note: The original text has been deleted

Reference materials:

[1]https://doi.

[4]https://jamanetwork.