Stem cell therapy for Alzheimer's disease shows positive potential

Recently, GABAeron announced positive preclinical research data obtained from Alzheimer's disease cell therapy based on induced pluripotent stem cells (iPSC)

Previous studies have shown that people carrying the APOE4 gene have a higher risk of Alzheimer's disease and an earlier age of onset.

In this study, scientists first successfully induced human iPSCs carrying the APOE3 gene to differentiate into GABAergic interneuron progenitor cells.

The researchers then transplanted them into the hippocampus of mice (10 months old) carrying the APOE4 gene

▲Poster displayed by GABAeron (picture source: reference [1])

Electrophysiological records show that the hippocampus activity of mice carrying APOE4 is defective, which may be the basis of memory impairment related to Alzheimer's disease

Reference materials:

[1] GABAeron Presents Promising Preclinical Data on Stem Cell-Based Therapy for Alzheimer's Disease.

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