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    Home > Active Ingredient News > Immunology News > Stem cell transplantation has made new progress in reversing Parkinson's complications!

    Stem cell transplantation has made new progress in reversing Parkinson's complications!

    • Last Update: 2021-03-25
    • Source: Internet
    • Author: User
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    Recently, a study published in the journal Nature Medicine showed [1] that transplanting neurons derived from Parkinson’s monkeys’ own cells and transplanting them into the brain can relieve the debilitating movement and debilitating activities associated with Parkinson’s disease.


    https://

    https:// align="justify" style="margin-top:20px;text-indent:2em;"> This research was funded by the National Institutes of Health (NS076352, NS096282, NS086604, U54 HD090256 and P51OD011106), the National Medical Research Council of Singapore, the Dr.


    Scientists have tried to treat advanced Parkinson's disease by implanting cells in fetal tissues, with some success, but the research and results are limited by the availability of cells and interference from the patient's immune system.


    The researchers injected millions of nerve cells (which can produce dopamine) into the striatum area of ​​each Parkinson's monkey.


    The scientists observed and evaluated the motor function after treatment (such as walking, grasping things, interacting with people, etc.


    It was found that within six months, the experimental group that received their own cell transplantation had a significant improvement.


    The study also found that the autologous transplanted nerve cell axons fuse with the surrounding tissues.


    The results of this study are full of new hope.


    Parkinson has become an epidemic

    Parkinson has become an epidemic

    Parkinson's disease is the second largest neurodegenerative disease after Alzheimer's disease and one of the most common movement disorders.


    Parkinson's disease is currently considered an epidemic.


    Its pathological feature is mainly the loss of midbrain dopamine (mDA) neurons.


    Stem cells will be a new milestone in Parkinson's treatment

    Stem cells will be a new milestone in Parkinson's treatment

    In fact, clinical and preclinical studies using a large number of embryonic stem cell transplantation have proved that cell replacement therapy may be a feasible treatment for Parkinson's disease [3].


    From the https://clinicaltrials.


    In the past, the transplanted dopamine cells could neither completely reconstruct the damaged or lost substantia nigra striatum circuit, nor could it improve all non-motor symptoms related to the disease.


    references:

    references:

    1.


    1.
    University of Wisconsin-Madison.
    "Individualized brain cell grafts reverse Parkinson's symptoms in monkeys.
    " ScienceDaily.
    ScienceDaily, 1 March 2021.
    < align="justify" style="margin-top:20px;text-indent:2em;"> 2.
    Marios Politiscorresponding and Olle Lindvall, Clinical application of stem cell therapy in Parkinson's disease.
    BMC Med.
    2012; 10: 1.
    https:// 2.
    Marios Politiscorresponding and Olle Lindvall, Clinical application of stem cell therapy in Parkinson's disease.
    BMC Med.
    2012; 10: 1.
    https:// align="justify" style="margin-top:20px;text-indent:2em;"> 3.
    Kai-C.
    Sonntag, Bin Song, Nayeon Lee,et.
    al.
    Pluripotent Stem Cell-based therapy for Parkinson's disease: current status and future prospects.
    Prog Neurobiol.
    2018 Sep; 168: 1-20.
    https:// 3.
    Kai-C.
    Sonntag, Bin Song, Nayeon Lee,et.
    al.
    Pluripotent Stem Cell-based therapy for Parkinson's disease: current status and future prospects.
    Prog Neurobiol.
    2018 Sep; 168: 1-20.
    https://
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