Stem cells don’t (just) play dice

Is all this accidental?

An important regulator of task assignment is to control genes through transcription factors such as NANOG and GATA, both of which were originally present in undifferentiated stem cells

Cell determines the collective

In a previous theoretical paper, Aneta Koseska, co-author of the study and former MPI team leader, established a new concept with the help of Christian Schröter , Showing how stem cells can be specialized in the right proportions in a coordinated way

Cheating in the stem cell dice game

In order to keep the cell's fate from changing, the researchers manipulated the NANOG-GATA dice in their study so that GATA now rolls more frequently than NANOG

Decisions are communicated in the team

According to their theoretical concepts, scientists have studied the role of cell communication in embryonic development

Christian Schröter said: "Communication in cell development is like working in a team

Dhruv Raina, Azra Bahadori, Angel Stanoev, Michelle Protzek, Aneta Koseska, Christian Schröter.