Sterilization technology of hydrogen peroxide dry fog

I properties of dry fog: dry fog refers to liquid particles with a diameter of 1-10 microns The properties of dry fog are as follows: (1) dry fog particles move irregularly (Brownian motion principle) and do not settle; (2) dry fog particles do not condense together to produce large droplets; (3) dry fog particles will rebound after contact with the surface, but will not break and make the surface moist Therefore, these properties of dry fog make its diffusion very good, leaving no dead angle when disinfecting; not wetting the surface; not corroding the equipment, color steel plate and wall And generally, the smaller the dry fog particles, the more obvious the characteristics of dry fog, the better the diffuse effect, and the better the sterilization effect II Principle of dry fog sterilization system: the dry fog sterilization system uses an electric motor, uses the principle of venturi to inhale air at high speed, and supplies enough kinetic energy to the air in the nozzle Make the gas collide with disinfectant at high speed to produce dry fog particles with diameter less than 5 microns The disinfectant is dispersed in the sterile and clean area in the form of dry fog particles, so as to achieve a thorough sterilization effect, which can replace fumigation This principle is well known in the world, but it needs to be solved: provide enough kinetic energy of air in an instant, heat dissipation and noise reduction, and occupy equipment space The unique boron cobalt alloy device nozzle with lubrication function designed by ofEM enlarges the efficiency of large-scale dry fog equipment, greatly reduces the space occupation, solves the problem of heat dissipation and noise reduction In any case, these technologies are the first in the world III The dry fog sterilization scheme consists of the olfim dry fog hydrogen peroxide sterilization equipment + novo space sporicidal agent The characteristics of Novo space sporicidal agent are as follows: (1) composition: hydrogen peroxide (produced by European special process, with high activity and low concentration) (2) imported from EU, colorless, tasteless, non-toxic, safe for human environment EU food safety certification (3) broad spectrum of germicidal efficacy: kill more than 200 microorganisms at the same time The killing rate of spores to black subtilis reached 6 per unit in 5 minutes (4) the verification data are complete: the detailed data of sterilization effectiveness verification, residue verification and material compatibility verification can be provided, which is easy to pass GMP verification (5) the product is widely used in Europe and North America Can pass the EU GMP, the US FDA The characteristics of olfim dry fog sterilization equipment: (1) brand: olfim, imported from France, 15 years of dry fog equipment technology accumulation (2) dry fog particles are less than 5 microns Zui best equipment for global dry fog effect (3) European professional application experience in the field of medicine, and sufficient European pharmaceutical factory validation experience (4) it is small in volume and light in weight, so it is convenient to use large space clean area and small space sterile room for sterilization (5) easy to move, power connection It is convenient for multi-point layout, and there is no dead space at all Designed for GMP IV the advantages of olfim hydrogen peroxide dry fog sterilization program: (1) the equipment, color steel plate and wall of Novo hydrogen peroxide dry fog sterilization program are guaranteed not to corrode in three aspects: ① compared with traditional hydrogen peroxide, our products are produced by special European processes, and the hydrogen peroxide activity is very high According to the test report of the disinfection center of the Chinese Academy of Military Medical Sciences (a testing institution qualified to test imported sterilization products in China), the germicidal efficacy of Novo is about 100 times that of the traditional hydrogen peroxide disinfectant under the same conditions So under the premise of fully ensuring the germicidal efficacy It is much lower than the traditional hydrogen peroxide ② the sporicidal agent of Zui in the world can kill 6-8 log units of Bacillus subtilis in 30 minutes, which is completely in line with the Pharmacopoeia The contact time between the disinfectant and the color steel plate of the equipment is greatly shortened (3) the global Zui dry fog effect ensures that the disinfectant is not attached and does not coagulate (experiments show that a piece of 1 square meter glass is placed at about 50 cm of the spray port of the equipment, no droplets are formed, and there is no wetting glass surface) (2) after sterilization, the product is decomposed into water and oxygen, without residue The verification data is sufficient, and there is a verification data template, which can help the enterprise to write the verification report quickly (3) the sterilizer can be controlled to spray out in the form of dry fog, and the size of dry fog particles can be controlled at the same level 3-5 μ m dry atomization effect, global *, reduce the risk of condensed liquid, and ensure the penetration and sterilization effect of relatively complex layout (4) flexible and portable (net weight: 5.8kg), which can be easily applied to laboratories, filling rooms and material warehouses of pharmaceutical enterprises (5) the whole sterilization process takes a short time, 2-3 hours to complete the whole "sterilization" process Compared with formaldehyde fumigation, the stopping time is greatly shortened Improve the production efficiency of enterprises (6) high cost performance, less than 1 / 10-1 / 20 of the cost of large-scale hydrogen peroxide gasification equipment, fully achieving the sterilization effect V scope of application of dry fog sterilization program (1) the dry fog sterilization program can be safely used for disinfection and sterilization of clean room space and equipment, and its application fields include pharmaceutical, biotechnology, medical product production, food production, cosmetics production and health care product production (2) the dry fog sterilization scheme can be safely used for sterilization of various levels: laboratory, microorganism room, aseptic room and aseptic transfer cabin (3) the dry fog sterilization scheme can be safely used for disinfection of stainless steel, plastic, glass, floor, wall and other surfaces and spaces Vi the sterilization effect of the dry atomized hydrogen peroxide sterilization system can be verified: the validation includes three parts: 1) validation of the sterilization effect of the dry atomized hydrogen peroxide 2) material compatibility validation (corrosiveness validation) 3) residue validation Ⅶ The operation direction of the dry atomized hydrogen peroxide sterilization system is as follows: * step: confirm the equipment location: the equipment location shall follow the following principles: 1 Priority shall be given to the core area 2, nozzles are far away from walls and equipment to avoid obscuring spray and easy to dry fog diffusion The second step: equipment in place, equipped with adequate disinfectant, connected to the power supply, according to the dosage of disinfectant set spray time Step 3: turn off the air conditioning, fresh air exhaust, and close the doors and windows The fourth step: start the button and start the spray button to start dry fog sterilization (please read the instructions before using the product) the fifth step: the equipment is bactericidal, and the spray will stop after the spray is finished Allow to stand for 60-90 minutes Fully exhaust for 30-60 minutes Disinfection is completed, and the whole disinfection process is about 3 hours.