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    Home > Food News > Nutrition News > Sticky bacteria are more resistant to antibiotics, leading to high patient mortality

    Sticky bacteria are more resistant to antibiotics, leading to high patient mortality

    • Last Update: 2023-01-06
    • Source: Internet
    • Author: User
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    Figure: The function of each gene is as follows: magA and rmpA: contribute to the viscosity
    of bacteria.
    fimH: involved in the adhesion
    of bacteria to infected host cells.
    uge and wabG: Involved in protecting bacteria from harm from the host's immune system
    iroB and iucA: Dealing with the
    host's iron.
    PEG-344: indicates high virulence

    Klebsiella pneumoniae is a bacterium
    that can cause a variety of infections.
    These bacteria are becoming increasingly resistant to treatment, leading to life-threatening diseases
    To address the lack of research on recent strains, a collaboration between Kobe and Taipei conducted a comparative analysis
    They took samples
    of a strain that produces broad-spectrum lactamase (ESBL) from infected patients in Japan.
    ESBL reduces the effectiveness
    of the -lactam antibiotics commonly used to treat infections such as penicillin and cephalomycin.
    In addition, some new strains have a high viscosity (HMV); They are thicker and stickier
    than previous varieties.
    By analyzing samples that produced the esbl strains, the researchers found that many HMV strains also carry a higher percentage of viral disease-causing genes, and traditional drugs are ineffective
    against them.
    These results have important clinical application value
    for establishing appropriate and rapid HMV strain treatment methods in Japan.

    The research was conducted by a 2nd Master's student including Tanimoto Hiroshi (Kobe University Graduate School of Health Sciences; Research supervisors: Associate Professor Shigemori Katsumi, Professor Orawa Kayo of Tokuwa University in Kobe, Japan, Assistant Professor
    Shibin Fang of Taipei Medical University, Taiwan.

    The findings were published in the Journal of Microbiology, Immunology and Infection (impact factor: 10.
    273) on August 20, 2022


    • The results of this study, conducted in Japan, showed that the High Viscosity (HMV)k.
      pneumonia strain had a higher virulence gene rate than previous strains and also showed higher drug resistance

    • The CTX-M-15 esbl-producing strain is the most prevalent
      The ability to produce ESBL makes these bacteria resistant to multiple antibiotics
      These findings suggest that the ESBL gene may be transmitted
      between plants via fii plasmids.

    is a bacterium that can cause a variety of infections, including urinary tract and respiratory tract infections
    Among these bacteria, high viscosity (HMV) K
    has been reported.
    Pneumonia, they are stickier than previous strains and cause a higher
    risk of severe illness and death.

    Previously, antibiotics were effective
    for most patients with HMV strains.
    However, in recent years, the presence of HMV strains producing prospectrase-lactamase (ESBL) has been confirmed
    ESBL is an enzyme that breaks down drugs, rendering them ineffective
    This is a serious problem because it means that in addition to the risk of serious disease, drug K
    has been used so far to be used to treat.
    Pneumonia is no longer effective
    against these new strains.

    In addition, the gene that produces esbl can be widely spread to other bacteria
    through plasmids (small DNA molecules).
    As these bacteria become increasingly resistant, it is crucial to monitor their characteristics and changes
    in different countries and over decades.
    However, no detailed investigation
    of HMV strains has been conducted in Japan.
    To solve this problem, the current research team conducted a comparative analysis of ESBL-producing strains from Japanese patients; HMV strains and previous non-HMV strains
    For each strain, they compared efficacy, resistance, virulence gene distribution, and plasmid type

    Methods Between 2012 and 2018,
    291 esbl strains produced K
    Among the infected patients with pneumonia in Japan, the class team investigated the efficacy, resistance, virulence genes and plasmid types
    of 107 strains (54 HMV strains and 53 non-HMV strains).

    The results showed that most HMV strains carried virulence genes and carried at a higher rate than non-HMV strains (Figure 1), suggesting that HMV strains had more virulence factors
    In addition, K.
    pneumonia capsule serotype has an effect
    on the viscosity of bacteria.
    This study found that among HMV strains, K2 capsule serotype was the most common (40.
    Previous investigations have also reported many strains of K2 HMV and are therefore considered highly likely K2 strains.
    Pneumonia is highly viscous accompanied by high toxicity

    To assess the effectiveness of the drug against these strains, the researchers used the β-lactam antibiotic cefepime (14.
    8% vs.
    4%, p=0.
    005) and piperacillin/tazobactam (70.
    4% vs.
    5%, p=0.
    001), a combination drug
    consisting of a β-lactam antibiotic (piperacillin) and an ESBL inhibitor (tazobactam).
    。 They confirmed that these drugs were less effective (susceptible) against HMV strains than non-HMV strains (Figure 2).

    These results suggest that HMV strains acquire resistance more frequently than non-HMV strains
    In other words, drugs are increasingly ineffective
    against them.

    Next, the team investigated the presence of genes associated with ESBL production, a major cause of
    drug resistance.
    They found that an ESBL-producing gene called CX-M-15 had the highest prevalence in HMV and non-HMV strains (75.
    9% and 60.
    4%, respectively), with the predominant plasmid type of the gene being FII (52.
    Studies conducted in other countries have also reported many K's
    Pneumonia and CTX-M-15 esbl produce gene, and current research shows an upward trend
    in strains with this gene in Japan.

    In summary, HMV strains have a high virulence gene rate and a high level of
    drug resistance.
    In addition, their findings also suggest that the most common esbl-producing gene type is CTX-M-15, and suggest that FII-type plasmids may spread CTX-M-15 widely to other strains

    Further research
    on HMVk.
    Pneumonia infection requires prompt treatment because of the high risk of severe disease
    In addition, improper medication is the main cause
    of drug resistance in these bacteria.
    To treat HMV strains, it is critical
    to have an accurate understanding of drug resistance and quickly select the appropriate drug.

    This study studies that current HMVk pneumonia carries higher virulence gene rates and less effective drugs targeting them than previous non-HMV strains
    These findings are expected to make a significant contribution
    to the appropriate and rapid treatment of HMV strains in Japanese hospitals.

    Further research into the mechanisms by which HMV strains cause severe disease and drug resistance will help establish new treatments


    Comparative genetic analysis of the antimicrobial susceptibilities and virulence of hypermucoviscous and non-hypermucoviscous ESBL-producing Klebsiella pneumoniae in Japan
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