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A paper published this week in Nature, Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence, pointed out that stress hormones inhibit hair growth by regulating hair follicle stem cells.
The study clarified the mechanism behind this phenomenon in mice and proposed possible methods to reverse the phenomenon.
The growth period and resting period of the hair follicle will switch continuously.
Rodent and human studies have shown that stress may affect hair growth, but the exact relationship between the two was previously unknown.
In order to determine the effect of stress on hair growth, Xu Yajie of Harvard University in the United States and colleagues studied how corticosterone (a hormone released by mice under chronic chronic stress) regulates the activity of mouse hair follicles.
Experiments in mice have shown that when corticosterone levels increase, the resting period of hair follicles will be prolonged and cannot be regenerated.
Conversely, if the level of corticosterone decreases, the hair follicle stem cells will be activated and start to grow new hair.
According to the author’s report, corticosterone can inhibit the activation of hair follicle stem cells by inhibiting the production of a protein called GAS6.
In the absence of corticosterone, GAS6 protein has been shown to promote the proliferation of hair follicle stem cells.
The author's research results indicate that restoring the expression of GAS6 protein may reverse the stress-induced suppression of hair follicle stem cells, and is expected to promote hair regeneration.
Rui Yi of the Feinberg School of Medicine at Northwestern University wrote in a news and opinion article published at the same time, "This exciting research result has laid the foundation for the development of treatments for long-term stress-induced hair loss.
" Rui Yi also pointed out that there are still many questions to be answered before the research results can be used in humans.
For example, corticosterone in rodents is thought to correspond to cortisol in humans, but we don’t know whether cortisol in the human body can also produce the effects observed here.
In addition, the long-term hair growth of mice and humans is different, which may affect the effectiveness of reversing stress-induced hair stem cell suppression.
GAS6 overexpression reversed the inhibitory effect of corticosterone.
The picture is from Hsu et al.
"Nature" News and Views: Relax to grow more hair long press and identify the QR code on the right, read the full text →©Nature Nature | doi: 10.
1038/ s41586-021-03417-2
The study clarified the mechanism behind this phenomenon in mice and proposed possible methods to reverse the phenomenon.
The growth period and resting period of the hair follicle will switch continuously.
Rodent and human studies have shown that stress may affect hair growth, but the exact relationship between the two was previously unknown.
In order to determine the effect of stress on hair growth, Xu Yajie of Harvard University in the United States and colleagues studied how corticosterone (a hormone released by mice under chronic chronic stress) regulates the activity of mouse hair follicles.
Experiments in mice have shown that when corticosterone levels increase, the resting period of hair follicles will be prolonged and cannot be regenerated.
Conversely, if the level of corticosterone decreases, the hair follicle stem cells will be activated and start to grow new hair.
According to the author’s report, corticosterone can inhibit the activation of hair follicle stem cells by inhibiting the production of a protein called GAS6.
In the absence of corticosterone, GAS6 protein has been shown to promote the proliferation of hair follicle stem cells.
The author's research results indicate that restoring the expression of GAS6 protein may reverse the stress-induced suppression of hair follicle stem cells, and is expected to promote hair regeneration.
Rui Yi of the Feinberg School of Medicine at Northwestern University wrote in a news and opinion article published at the same time, "This exciting research result has laid the foundation for the development of treatments for long-term stress-induced hair loss.
" Rui Yi also pointed out that there are still many questions to be answered before the research results can be used in humans.
For example, corticosterone in rodents is thought to correspond to cortisol in humans, but we don’t know whether cortisol in the human body can also produce the effects observed here.
In addition, the long-term hair growth of mice and humans is different, which may affect the effectiveness of reversing stress-induced hair stem cell suppression.
GAS6 overexpression reversed the inhibitory effect of corticosterone.
The picture is from Hsu et al.
"Nature" News and Views: Relax to grow more hair long press and identify the QR code on the right, read the full text →©Nature Nature | doi: 10.
1038/ s41586-021-03417-2
