Stress granules can lead to obesity-related pancreatic cancer

Obesity is a known risk factor for at least 13 types of cancer, in part because it creates a long-standing inflammatory state

"Research on stress particles is now exploding, but there's still a lot we don't know about their composition and mechanism of action," said Dr Grabocka, a researcher at the Sydney Cammore Cancer Center-Jefferson Health Centre and an assistant professor at

Pressure particles are an unusual type of cell chamber

Knowing this, Dr.

"Now," Dr.

The researchers took two different types of obese mouse models — mice with a genetic predisposition to overeating and the other mice on a high-fat diet — and looked at pancreatic cancer

Dr Grabocka said: "When we stopped the stress particle formation in these obese mice with pancreatic cancer, the results were really quite surprising

The most significant difference is their overall survival rate

These experiments show that stress particles are not only present in cancer cells, they actually drive cancer growth

Importantly, Dr.

"Conditions of cellular stress, such as obesity, increase the number of stress particles in cells and may drive the formation of pancreatic cancer and other cancers," Dr.

Stress granules determine the development of obesity-associated pancreatic cancer