Stroke: After cerebral hemorrhage, persistent high blood sugar may increase the risk of death and disability

The American Heart Association/American Stroke Association guidelines point out that the best treatment for hyperglycemia in patients with intracerebral hemorrhage (ICH) remains to be clarified
.

The guidelines state that serum glucose should be monitored and hypoglycemia and hyperglycemia should be avoided (Class I; Level of Evidence C)

Guide to hypoglycemia

Wu et al.
reported the relationship between hyperglycemia (mainly based on a single measurement) and hypoglycemia
.

Most studies focused on mortality at different time points after ICH, and showed an inconsistent relationship with mortality after discharge

Recent studies have evaluated the impact of baseline or admission serum glucose on functional outcomes
.

However, single-center retrospective studies have shown that hyperglycemia that lasts for 24 hours or more may be associated with adverse outcomes (defined by the Glasgow Outcome Score at discharge or 6-month mortality)

In order to further explore the impact of persistent hyperglycemia on ICH patients, Adnan I.
Qureshi of the University of Missouri in the United States explored the direct effect of persistent anti- hypertensive large number of patients treated) into the group, according to the blood sugar condition assessment to strengthen the efficacy of the standard buck buck
.

hypertension

They defined moderate and severe hyperglycemia based on serum glucose levels ≥140 -180 and ≥180 mg/dL measured at baseline, 24, 48, and 72 hours
.

Persistent hyperglycemia is defined as two consecutive (24-hour intervals) serum glucose levels

diabetes

They found that in a multivariate analysis, moderate (probability ratio, 1.

8[95% CI, 1.
1-2.

In patients without pre-existing diabetes, after adjusting for the above potential confounding factors, moderate (probability ratio, 1.
8[95%CI, 1.
0-3.
2]) and severe (probability ratio, 2.
0[95%CI, 1.
1-3.
7] ]) Hyperglycemia is all related to 90 days of death or disability
.

In patients with pre-existing diabetes, moderate and severe hyperglycemia are not related to 90 days of death or disability
.

The significance of the study is that it found that persistent hyperglycemia, whether moderate or severe, will increase the risk of death or disability in patients with non-diabetic intracerebral hemorrhage
.

Persistent hyperglycemia, whether moderate or severe, increases the risk of death or disability in non-diabetic patients with intracerebral hemorrhage

Original source:
  Qureshi AI, Huang W, Lobanova I, et al.

Effect of Moderate and Severe Persistent Hyperglycemia on Outcomes in Patients With Intracerebral Hemorrhage.
Stroke.

Effect of Moderate and Severe Persistent Hyperglycemia on Outcomes in Patients With Intracerebral Hemorrhage.
Leave a message here