Stroke: After successful reperfusion with endovascular therapy, the greater the drop in blood pressure, the better the outcome!

Endovascular therapy (EVT) has revolutionized the treatment of acute ischemic stroke caused by large vessel occlusion

Despite high recanalization rates, approximately half of treated patients did not achieve functional independence after EVT

Observational studies in hypertension have repeatedly demonstrated an association between hypertension and poor outcomes after successful reperfusion, a finding that is also supported by preclinical studies

This is a post hoc analysis of the BP-TARGET multicenter trial

RESULTS: A total of 267 patients (130 in the intensive treatment group) were included

After adjusting for potential confounders including baseline SBP, both ΔSBP15-60M and ΔSBP6-24H reductions were significantly associated with lower odds of adverse outcome (OR = 5 mmHg SBP reduction, respectively, 0.

A reduction in ΔSBP15-60M was significantly associated with a lower chance of any intravascular hemorrhage (OR = 5 mmHg SBP reduction, 0.

Taken together, ΔSBP was linearly associated with adverse outcomes after successful reperfusion, with the lesser the decrease in SBP from baseline, the higher the risk of adverse outcomes

Taken together, ΔSBP was linearly associated with adverse outcomes after successful reperfusion, with the lesser the decrease in SBP from baseline, the higher the risk of adverse outcomes

references:

Magnitude of Blood Pressure Change After Endovascular Therapy and Outcomes: Insight From the BP-TARGET Trial.

Magnitude of Blood Pressure Change After Endovascular Therapy and Outcomes: Insight From the BP-TARGET Trial.
https://doi.
org/10.
1161/STROKEAHA.
121.
036701

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