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Carotid stenosis is ischemic stroke, a major risk factor, accounting for 8% of stroke events
Stroke
Preventive management
The secondary outcome of CREST-2 is the effect of treatment on changes in cognitive function, which is evaluated at baseline and annually thereafter
Blood vessel
Main hypothesis: The baseline cognitive test scores of CREST-2 patients will be significantly lower than those of participants in the REGARDS cohort, and adjustments will be made to (1) age, education, and race; (2) further adjustments to the development of carotid arteriosclerosis and cognitive impairment Related cardiovascular risk factors (hypertension, diabetes , dyslipidemia, and smoking)
Cardiovascular Diabetes
Because of the well-recognized link between widespread stroke and cognitive performance, the study excluded CREST-2 participants who reported having a stroke at baseline
In this way, Ronald M.
Patients with carotid artery stenosis are older than 45 years old, asymptomatic carotid artery stenosis is ≥70%, and there is no history of epidemic stroke
There are 786 baseline assessments
They found that the overall Z score of the patient was significantly lower than expected in the higher percentile (P<0.
The patient’s overall Z score was significantly lower than expected in the higher percentiles (P<0.
The important significance of this study is that it found that the baseline cognition of patients with severe carotid artery stenosis was lower than normal cognition when demographic and cardiovascular risk factors were controlled
After controlling for demographics and cardiovascular risk factors, the baseline cognition of patients with severe carotid artery stenosis showed lower than normal cognition
.
Baseline Cognitive Impairment in Patients With Asymptomatic Carotid Stenosis in the CREST-2 Trial.
Stroke
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