Stroke: Different cardiovascular diseases are closely related to cognitive decline

The pathology of cerebrovascular disease (CVD) increases with age and is a common neuropathological comorbidity of neurodegenerative diseases including Alzheimer's disease (AD)
.

Blood vessel

 

Although there are reports that 33% to 75% of the dead are found to have AD-related neuropathology, they also show CVD, including vascular diseases (arteriosclerosis, atherosclerosis, and cerebral amyloid angiopathy [CAA]) and Tissue damage (large infarcts and micro-infarcts), but little is known about the most common frequency and combination of CVD
.

This is especially important because researchers are beginning to believe that for cognitive aging and dementia, it is not just the number of symptoms that are important, but the types of symptoms that coexist

Although some have outlined the different relationships between individual CVD-related neuropathology and cognition, few studies have systematically examined the frequency of 32 possible CVD vascular disease and tissue damage pathological combinations to determine the most common combination , And then assess the association with cognition
.

However, few studies have systematically examined the frequency of 32 possible CVD vascular disease and tissue damage pathological combinations to determine the most common combination, and then assess the association with cognition
.

Therefore, Melissa Lamar of Rush University Medical Center et al.
systematically examined the three types of vascular diseases (arteriosclerosis, atherosclerosis, and CAA) found in the community clinical neurology cohort study of the Rush Alzheimer’s Center.
) And 32 possible CVD combinations of 2 types of tissue damage (large infarct and micro infarction) to determine the most common CVD pathological features
.

The second purpose is to determine the relationship between the resulting CVD portfolio and changes in global and domain-specific cognitive function
.

Based on literature related to individual CVD neuropathology and cognition

Core hypothesis: When considered in the same model, the mixed CVD profiles will be those most often associated with cognitive decline, especially perceptual speed, profiles involving arteriosclerosis and/or atherosclerosis, and working memory and visual spatial capabilities There are different links to the decline in specific areas of the country
.

They used the autopsy data of 1474 people (aged over 88 at death; 65% women) studied by the Rush Alzheimer's Center to investigate 32 possible combinations of cardiovascular diseases (3 vascular diseases and 2 tissues).
Damage)
.

And determined the frequency of all 32 CVD combinations and their relationship with global and specific domain cognitive decline, using a mixed-effect model to adjust demographics, neuropathology, time before death, and the interaction of these variables with time

Cardiovascular

Among the 1184 deaths with CVD neuropathology (80% of the total sample), 37% had a single CVD (67-148 deaths/group), and 63% had a mixed CVD situation (11-54 deaths/group) )
.

When viewed as two distinct groups, the mixed CVD feature group (but not the single CVD feature group) showed faster cognitive decline in all areas evaluated than the dead without CVD neuropathology
.

Most mixed CVD data, especially those involving both atherosclerosis and arteriosclerosis, show faster cognitive decline than any single CVD data considered separately; specific mixed CVD data are different from individual cognitive domains ’S association
.

The important significance of this research lies in the discovery that mixed CVD is more common than single CVD and is related to cognitive decline .
Different characteristics of mixed CVD and cognitive decline show a specific field of association
.

CVD is not single, but is composed of heterogeneous, individual-specific combinations, which have different contributions to the decline of cognitive ability

Mixed CVD is more common than single CVD and is related to cognitive decline

Original Source:
Lamar M, Leurgans S, Kapasi A, et al.

Complex Profiles of Cerebrovascular Disease Pathologies in the Aging Brain and Their Relationship With Cognitive Decline .
Stroke.

Complex Profiles of Cerebrovascular Disease Pathologies in the Aging Brain and Their Relationship With Cognitive Decline

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