Stroke: Fudan University Huashan Hospital research, nerve wire light chain can reflect the severity of cerebrovascular disease

Cerebral microvascular disease (CSVD) is a common heterogeneous disease that affects the small meninges and intra-cavity arteries, arteries, capillaries and veins in the brain that originate from the subcavity of the cobwebs or large intra-cavity arteries.
neuroimaging CSVD markers include small subsurgery infarction, fissure infarction (LIs), high white matter signal lesions (WMHs), enlarged space around blood vessels, cerebral micro-bleeding (CMBs), and brain atrophy.
CSVD is recently considered a dynamic whole-brain disease due to its common microvascular pathology, diffuseness, and different advances in its lesions.
addition, it has been identified as a common cause of stroke and a major subtype of vascular cognitive impairment.
Magnetic Resonance Imaging (MRI) as one of the most effective ways to monitor the dynamic changes and progression of CSVD, it has several limitations and is expensive, time-consuming, and not suitable for patients with taboos.
use of MRI for longitudinal tracking and early intervention of CSVD is limited by its inability to use in many primary health care centers.
nerve wire light chain (NfL) is the main intermediate component of the axon cytostic skeleton, providing mechanical support and regulating the size of the axon.
During axon damage, it is released into extracellular space and then into cerebrospinal fluid (CSF) and blood; The increase in NfL levels in blood and CSF in patients with
indicates that it can be used as a nonsexual predictor or diagnostic biomarker for neurodegenerative neuroassopathic injuries in a variety of acute and chronic neurological diseases, such as Alzheimer's disease, preclinical dementia, multiple sclerosis, and brain trauma.
because lumbar puncture is an invasive procedure, monitoring CSF NfL levels has little or no vertical variation.
, plasma NfL measurements are considered a convenient and relatively invasivable tool that can provide effective information on neuron damage to the central nervous system at a lower cost than imaging examinations.
recent studies have validated NfL as a blood biomarker of CSVD MRI markers, suggesting the potential role of NfL in CSVD monitoring.
this, a team of professors of neurology at Huashan Hospital, affiliated with Fudan University, used the famous Alzheimer's Disease Neuroimaging Initiative (ADNI) to explore the relationship between NfL and SVD.
they included 496 non-dementia participants in the ADNI database.
all participants were measured with plasma NfL and 3.0-Tesla brain magnetic resonance imaging, and 387 (78.0%) were measured vertically.
measured the number of micro-bleeding, cavity infarction and volumetric whiteness in the brain, as well as Fazekas scores.
use a multivariate adjustment model to evaluate the cross-sectional and vertical associations between the CSVD burden and the NfL level.
results show that plasma NfL is higher in CSVD burden.
baseline, plasma NfL (45.2±16.0pg/mL) in the moderate-heavy CSVD burden group was higher than in the non-burden group.
NfL was positively associated with micro-bleeding of the brain (OR=1.29), cavity gap infarction (OR=1.43) and moderate to severe WMH (OR=1.67).
from a longitudinal point of view, a higher NfL change rate can predict more CSVD burden progress (OR=1.38), WMH (OR=1.41), and cavity infarction (OR=1.99).
significance of this study is the discovery that plasma NfL levels are a valuable non-invasive biomarker that can complement magnetic resonance imaging scans and may reflect the severity of the CSVD burden.
addition, high plasma NfL levels tend to represent an increase in CSVD risk, and a dynamic increase in NfL levels may predict greater progression of CSVD.
origin: Association of Plasma Neurofilament Light Small Vessel Disease Burden in Nondemented Elderly, A Longitudinal StudyYi Qu, Chen-Chen Tan, Xue-Ning Shen, Hong-Qi Li, Mei Cui, Lan Tan, Dong Qiang, Jin-Tai Yu, on behalf of the Alzheimer's Disease Neuroimaging† StrokeFreeman Source: MedSci Original Copyright Notice: All text, images and audio and video materials on this website that state "Source: Mays Medicine" or "Source: MedSci Original" copyrights are owned by Mays Medicine No media, website or individual may be reproduced, and authorization must be made with the "Source: Metz Medicine" in the authorizing the reprint.
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