Stroke: The rate and related factors of seizures after stroke re-perfusion treatment.

In a recent study published in Stroke, a leading journal in the field of cardiovascular disease, researchers conducted a systematic evaluation and meta-analysis to assess the incidence and risk of seizures after acute stroke re-perfusion therapy (using r-tPA (recombinant tissue-type lysolysase activator) for venous thrombosis (IVT), mechanical thrombosis, or both).
researchers searched the main databases (MEDLINE, SCOPUS and Cochrane Library) for literature published between 1995 and October 28, 2019.
outcome of this study was the overall and treatment-specific combined rate of seizures (PSS) after acute stroke re-perfusion therapy.
studies, the researchers also calculated the combined rate of early seizures after stroke and late seizures after stroke.
researchers were given the risk of IVT-related PSS in a queue of IVT-only patients.
few studies have reported that mechanical thrombotomy alone or in combination with IVT can lead to PSS risk, so researchers were unable to calculate estimates of the risk of seizures associated with the therapy.
researchers identified 13,753 stroke patients, 592 of whom had seizures.
of PSS was 5.9% (95% CI was 4.2%-8.2%).
in stroke patients treated with IVT and mechanical thrombotomy, the PSS rate was 6.1% (95% CI was 3.6%-10.2%), 5.9% (95% CI was 4.1%-8.4%) and 5.8% (95% CI was 3.0%-10.9%).
rate of late-stage PSS was 6.7% (95%CI was 4.01%-11.02%), and the rate of early PSS was 3.14% (95% CI was 2.05%-4.76%).
ratio associated with IVT and PSS is 1.24 (95% CI is 0.75-2.05).
results of this meta-analysis showed that for every 15 ischemic stroke patients treated with IVT and/or mechanical thrombotomy, seizures occur regardless of whether or not they receive specific re-perfusion therapy.
.