Stroke: The ratio of neutral granulocytes to lymphocytes predicts early cerebral edema and clinical deterioration in stroke patients after refilling

The mechanism of correlation between systemic inflammation and poor prognosis of ischemic stroke is not yet clear.
, researchers looked at whether inflammation around the treatment after refilling causes increased cerebral edema (CED), which is detrimental to a patient's clinical recovery, according to a recent study published in the leading journal cardiovascular disease.
conducted a single-center study at Centro Hospital between 2017 and 2019.
included in the study were adult patients with pre-circulating acute ischemic stroke who received refill therapy.
researchers determined the ratio of neutral granulocytes to lymphocytes, plates to lymphocytes, and criteria for systemic inflammatory response syndrome.
a computer fault scan 24 hours after the event to assess the extent and severity of the CD.
clinical outcomes of the study included early 90-day neurologic deterioration and functional dependence.
the researchers obtained an adjusted ratio of 95% CI through sequential and Logistic regression models.
researchers determined the optimal threshold by analyzing the subject's operational characteristics in the training queue and validated it in a separate data set.
the study included 553 patients.
neastatic granulocyte-lymphocyte ratio increases with the increase in CED severity within 24 hours (correction ratio of 1.34 (1.09-1.68), P<0.01) and deteriorates with early neural function (correction ratio ratio of 1.1. 30 (1.04-1.63), P<0.05) and 90 days of poor function (correction ratio of 1.79 (1.28-2.48), P less than 0.01).
the ratio of plateplates to lymphocytes had nothing to do with outcome.
systemic inflammatory response syndrome was associated with CED due to changes in white blood cell counts.
-lymphocyte ratio is the best predictor, with an area of about 0.7 among the lower curves.
the ratio of neutral granulocytes to lymphocytes ≥7, its accuracy, sensitivity and specificity are about 60%.
can be seen that systemic inflammation is associated with the severity of early CED after stroke refill therapy.
easily available inflammatory markers may send early warning messages to patients with severe neurological complications and long-term functional outcomes.