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Vitamin B supplements can reduce the circulatory concentration of high cysteine and may reduce the risk of stroke.
concentration of homocysteine was associated with the rate of stroke, but the association between other sulfur-containing compounds in the associated metabolic pathways and cerebrovascular disease has not been studied.
researchers conducted a case-control study that included 480 patients with cerebrovascular disease and 480 controls matching the years of age, gender and baseline examination (1993-1997).
researchers used baseline plasma samples to determine levels of sulfur-containing compounds, including methionine, homocysteine, cysteine, cysteine, glutathione and taurine, using liquid chromatography-series mass spectrometry.
researchers assessed the relationship between the concentration of each compound and methionine to homocysteine (representing a carbon metabolic activity) and the risk of cerebrovascular disease, and adjusted for potential confluum factors.
plasma methionine and methionine/homocysteine ratios were negatively associated with the risk of cerebrovascular disease, with a ratio of 0.83 (95% CI 0.72-0.96) and 0.82 (95% CI 0.71-0.95) for each additional SD.
the same type of cysteine, the association between methionine and the risk of cerebrovascular disease remained significant.
other assessed compounds were not related to cerebrovascular disease.
results suggest that higher bioavailable use of methionine may play a role in preventing cerebrovascular disease and explain the previously known relationship between homocysteine and stroke.
further research is needed to determine the cause and potential of circulating methionine as a target for the prevention of cerebrovascular diseases.
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