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In clinical work, the speed of drug infusion has a large or small effect on efficacy, adverse reactions and patient circulatory system.
the particularity of chemotherapy drugs and tumor patients, it is more necessary to strictly grasp the infusion speed, while increasing the efficacy of the drug, to minimize adverse reactions.
to facilitate clinical and reasonable control of the rate of infusion of chemotherapy drugs, summarized below, with a view to clinical help.
administration of chemotherapy drugs, according to the speed can be divided into intravenous push, rapid infusion, slow infusion, first slow and then fast.
the choice of infusion mode of chemotherapy drugs mainly consider the following factors: 1. Drug action characteristics, including half-life, distribution characteristics, mechanism of action, etc. are different; Drug stability factors, most chemotherapy drugs are sensitive to light, heat and other environment, poor stability, long infusion time can affect the efficacy of the drug or increase the occurrence of adverse reactions;
The infusion time requirements for common chemotherapy drugs are as follows: 1. Yew alcohol yew alcohol infusion usually requires a drip time greater than 3 hours, yew alcohol preparations contain high doses of ethanol, infusion in a short period of time may lead to central nervous system toxicity, combined use of antihistamines can enhance this effect.
is the main dose-limiting toxicity of yew alcohol, and severe neutral granulocytic deficiency can lead to infection.
it was reported that bone marrow inhibition caused by yew alcohol was associated with dose and dosage time, where the effect of dosage time was more prominent, with severe neutral granulocyte reduction occurring over a 24-hour period of infusion more frequently than 3-hour infusion.
the occurrence of mucositis is also time-dependent, with the occurrence of infusions at 24 hours higher than the rate of infusions at 3 hours.
2. Osari platinum is reported to be associated with acute exonym neurotoxicity associated with cold stimulation and infusion time.
if the patient has acute exotoxic symptoms, prolonged infusion time in later treatment can reduce the risk of symptoms.
if the patient experiences acute throat spasms when the drug is given at the rate of Osali platinum within 2 hours, the next drip should be extended to 6 hours.
Osali platinum can only be stored at room temperature for 4 to 6 hours after dilution by 5% glucose injection, so infusion time should not exceed 6 hours.
3. Elite Coni Litecon cannot be administered intravenously and requires intravenous drips for no less than 30 minutes or more than 90 minutes.
4. Eposide etoposide should not be pushed intravenously, static drip time must not be too fast, at least half an hour, otherwise it is easy to cause low blood pressure, throat spasms and other allergic reactions.
5. The half-life of Gissithamin is affected by the infusion time, and the toxicity increases if the frequency of use exceeds 1 time per week or if the infusion time exceeds 60 minutes.
reported an increase in toxicity when Gisithabin was used more than once a week or for more than 60 minutes.
assessed the maximum tolerance for infusion time in the Phase I study and found that once a week, at 300 mg/m2, the infusion time exceeded 270 minutes with clinically significant toxicity and bone marrow inhibition.
6. Fluorouracil fluorouracil is a cell cycle-specific drug that mainly inhibits stage S cells, the slower the drip rate, the better the efficacy, and the less toxic side effects.
intravenous drip time must not be less than 6 to 8 hours, can be used infusion pump continuous dosage for 24 to 48 hours.
7. Tiniposide intravenous infusion time is not less than 30 minutes, in order to reduce the possibility of hypotension reaction, Tiniposide should not be pushed intravenously or intravenously rapid infusion.
can occur after rapid intravenous infusion of tinipolycoside, there have been reports of sudden death due to arrhyth arrhythmic and hypotension.
8. Changchun Ruibin Changchun Ruibin is highly irritating to blood vessels and tissues, after osmeal can appear serious tissue damage, it is recommended that the center of intravenous drug, 15 to 20 min after the drop with physiological saline flushing tube.
9. Methotrexate high-dose methotrexate therapy is prone to serious adverse reactions, must be hospitalized and may be monitored at any time when the concentration of blood drugs can be used carefully, intravenous drip time should not exceed 6 hours, drip is too slow to increase renal toxicity.
10. Dakaba diodakabazine in the light and thermal instability is red, dissolved after instability, is now available, infusion needs to avoid light, should not be too slow.
11. Mono-anti-drug quercimal bead monoantigen, lysoxi monoantigen, beva bead monoantigen, sitoxys monoantigen and other monoclonal antibody drug infusion reaction is usually more serious, the infusion speed is related to the severity of the infusion reaction, for patients with mild to moderate infusion reaction should reduce the infusion speed.
the first use of such drugs usually requires slow infusion, if the patient is well-to-do, can gradually increase the speed of drug infusion.