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    Home > Active Ingredient News > Infection > STTT Guangxi Medical University multi-unit cooperation, Zhao Yongxiang/Dong Xiaochen/Yang Dongliang to develop new nanomaterials to better treat multi-drug resistant bacterial infections

    STTT Guangxi Medical University multi-unit cooperation, Zhao Yongxiang/Dong Xiaochen/Yang Dongliang to develop new nanomaterials to better treat multi-drug resistant bacterial infections

    • Last Update: 2022-04-28
    • Source: Internet
    • Author: User
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    iNature bacterial infections afflict millions of people around the world each year and pose a serious threat to public health
    .

    The advent of antibiotics has greatly eased the suffering of infected patients
    .

    However, the misuse of antibiotics has accelerated the evolution of multidrug-resistant strains, which has brought great difficulties to antibiotic-dependent treatments
    .

    Therefore, there is an urgent need to discover new antibiotic-free antibacterial pathways to solve this problem
    .

    The current feasibility of nanocatalysts in clinical anti-infective therapy, especially for drug-resistant bacterial infections, is greatly limited due to insufficient production of reactive oxygen species
    .

    On March 28, 2022, Zhao Yongxiang from Guangxi Medical University, Dong Xiaochen and Yang Dongliang from Nanjing University of Technology jointly published an online publication entitled "POD Nanozyme optimized by charge separation engineering for light/pH activated bacteria" in Signal Transduction and Targeted Therapy (IF=18) catalytic/photodynamic therapy”, which prepared Ag/Bi2MoO6 NPs (Ag/BMO NPs) with enhanced catalytic activity under NIR-II light for synergistic nanozyme antibacterial therapy and NIR-II photodynamic antibacterial therapy
    .

    The Ag/BMO nanozyme exhibited satisfactory bactericidal performance (~99.
    9%) against methicillin-resistant Staphylococcus aureus (MRSA)
    .

    The excellent antibacterial properties of Ag/BMO NPs are attributed to peroxidase activity, NIR-II photodynamic behavior, and acid-enhanced Ag release
    .

    As revealed by theoretical calculations, the introduction of Ag into the BMO makes it easier to separate light-triggered electron-hole pairs for ROS generation
    .

    Ag/BMO NPs favor the reduction of O2 to ·O2-
    .

    Under 1064 nm laser irradiation, electron transfer to BMO facilitates the reversible change of Mo5+/Mo6+, which further enhances the peroxidase-like catalytic activity and NIR-II photodynamic performance based on the Russell mechanism
    .

    In vivo, Ag/BMO NPs showed promising therapeutic effects on MRSA-infected wounds
    .

    In conclusion, this study enriches the research on nanozymes and demonstrates that nanozymes can be rationally optimized by charge-separation engineering strategies
    .

    Bacterial infections afflict millions of people around the world each year and pose a serious threat to public health
    .

    The advent of antibiotics has greatly eased the suffering of infected patients
    .

    However, the misuse of antibiotics has accelerated the evolution of multidrug-resistant strains, which has brought great difficulties to antibiotic-dependent treatments
    .

    To make matters worse, the development of new antibiotics has lagged the growth of multidrug resistance
    .

    Therefore, there is an urgent need to discover new antibiotic-free antibacterial pathways to solve this problem
    .

    Recently, nanoenzyme antibacterial therapy has emerged as a potential therapeutic strategy with broad-spectrum antibacterial activity
    .

    In general, nanoenzyme antibacterial therapy can kill bacteria by using man-made nanomaterials with inherent enzyme-like activities, eg, catalyzing hydrogen peroxide (H2O2) to form cytotoxic hydroxyl radicals (·OH)
    .

    Subsequently, these generated ROS (such as OH) can attack and destroy bacterial membranes, DNA, and proteins at the site of acidic infection, further leading to bacterial inactivation
    .

    Notably, compared with antibiotics, bactericidal strategies based on the generation of reactive oxygen species (ROS) can significantly avoid the occurrence of drug resistance
    .

    Currently, various nanozymes including carbon and metal oxide/chalcogenide nanomaterials have been successfully used as antibacterial agents
    .

    However, the insufficient catalytic activity of nanozymes makes achieving the desired antibacterial efficiency problematic
    .

    Preparation of Ag/BMO Nanozyme and Mechanism of Near Infrared Enhanced Catalytic Activity for Synergistic Bacterial Therapy
    .

    However, the catalytic activity of pure Bi2MoO6 is limited due to its fast electron-hole recombination rate and low carrier mobility
    .

    To address these defects, plasmonic metallic materials (e.
    g.
    , Au, Ag), which typically have negative dielectric constants, are introduced to enhance catalytic performance with the help of visible light by increasing the charge separation lifetime and interfacial charge transfer capability
    .

    However, the poor penetration depth of visible light hinders the application of Bi2MoO6 in the biomedical field
    .

    In contrast, NIR-II light with greater tissue penetration and higher maximum allowable exposure shows great potential in biomedical photonics
    .

    Herein, Ag/Bi2MoO6 NPs (Ag/BMO NPs) with enhanced catalytic activity under NIR-II light were prepared for synergistic nanozyme antibacterial therapy and NIR-II photodynamic antibacterial therapy (PDAT)
    .

    With the introduction of Ag, the engineered Ag/BMO NPs exhibited strong NIR-II absorption
    .

    The enzyme-like activity analysis confirmed that the Ag/BMO nanozyme exhibited enhanced peroxidase-like catalytic performance under NIR-II light
    .

    In addition, NIR-II PDAT produces a large amount of singlet oxygen upon 1064 nm laser treatment
    .

    All antibacterial results indicated that Ag/BMO NPs with satisfactory biocompatibility could effectively eradicate methicillin-resistant Staphylococcus aureus (MRSA) assisted by a 1064 nm laser
    .

    Furthermore, the working mechanism of self-replenishment, sustainability, and coupled synergy of cascaded nanocatalytic reactions is carefully revealed by density functional theory (DFT) calculations
    .

    This study demonstrates that Ag/BMO NPs nanozymes with NIR-II-enhanced peroxidase-like properties and NIR-II photo-activated PDT hold great promise in the field of anti-infective therapy
    .

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