Studies have found that bacteria are the key to vaginal health

By Melissa Herbst-Kralovetz, a member of the BIO5 Institute and associate professor of basic medical sciences-Phoenix, the researchers found that the family of the Veillonellaceae bacteria cause inflammation and cell death, increasing and changing the acidity of the cervical microenvironment

"Bacterial vaginosis is a mystery," said Dr.

Paper "The Veillonellaceae family is the only three-dimensional epithelial model that changes the cervical metabolic microenvironment in humans," published on July 6 in "npj Biofilm Microorganisms, and found that members of the Veillonellaceae family cause diseases by altering inflammation and metabolism in the cervicovaginal region

The female reproductive tract is usually colonized by health-promoting bacteria, such as lactic acid bacteria

Last year, Dr.

Dr.

They found that two bacteria, atypical Vibrio and Vibrio Montpellier, can reduce the content of lactic acid.

They also found that Mycoplasma micronucleus promotes cell death by increasing inflammation and the production of certain fat molecules, thereby further promoting disease progression

The results of this research lay the foundation for multi-microbial or "multi-bacteria" research, which can determine the complex interactions of multiple bacterial species on female reproductive health

"Using this research and our 3D model as a basis, we hope to determine whether and how other species change the environment to cause bacterial vaginosis," Dr.

Dr.

She said: "It is important to know who are the main participants and how they affect physiological processes and diseases, so that we can develop targeted strategies to treat bacterial vaginosis and prevent subsequent gynecological infections.

The co-authors of Dr.

The research was partially funded by the National Cancer Institute under the National Institutes of Health and the Office of Women's Health Research (3P30CA023074-39S3) and the Folin Foundation (2244)

Journal Reference :

1. Mary E.