Studies have revealed a new mechanism for nitric oxide inhibition of Pseudomonas aeruginosa

Pseudomonas aeruginosa (PA), also known as Pseudomonas aeruginosa, accounts for 10% to 15% of global nosocomial infections, the infection fatality rate of Pseudomonas aeruginosa is as high as about 38%, and the current treatment regimen is mainly focused on antibiotic treatment, and drug resistance is a challenge

PA's argU is a sigma factor of extracellular function, which is responsible for the oversynthesis of alginate, which forms a thick mucus outside the cell, reducing the permeability of its outer membrane to produce resistance, contributing to the long-term survival

The related research has been funded by the National Key Research and Development Program of Protein Machine and Life Process Regulation, the Strategic Pilot Science and Technology Project of the Chinese Academy of Sciences (Category B), the Major Research Program of the National Natural Science Foundation of China, the Youth Fund of the National Natural Science Foundation of China, and the Shaanxi Academy of Sciences

Pattern diagram of nitric oxide inhibition of Alginate hypersynthesis of Pseudomonas aeruginosa

Source: Institute of Biophysics, Chinese Academy of Sciences