Studies have revealed the dynamic processes of individual Ebola virus invading cells

chinese researchers used techniques such as single-particle force d tracer to reveal in real time the dynamic processes and dynamic mechanisms of individual Ebola virus invading cells. The findings are important for understanding the ebola virus infection pathways in depth and for developing antiviral pathways.The Ebola virus is one of the deadliest pathogens in humans, causing severe haemorrhagic fever with a fatality rate of up to 90%. Researcher Cui Zongqiang of Wuhan Virus Research Institute of the Chinese Academy of Sciences, in collaboration with Professor Shan Yuping of Changchun University of Technology and Shi Xinghua Researcher of the National Nanoscience Center, conducted a study on the invasion of cells of a single Ebola virus.
The researchers first constructed silk Ebola virus-like particles and fluorescently labeled them. The silky Ebola virus-like particles have the same invasive capability as the wild Ebola virus, but they do not have viral nucleic acids inside and cannot be replicated. Using techniques such as single-particle force tracer, dynamic simulation, and single-particle fluorescence tracer, the researchers traced the dynamic process of individual Ebola virus-like particles invading cells and analyzed their dynamic mechanisms.The study revealed detailed mechanisms such as silk Ebola virus-like particles entering cells in both horizontal and vertical modes, as well as the corresponding space-time, energy, mode of action with the subject, invasion pathway, and visually confirmed that silk Ebola virus-like particles invaded cells by drinking giant cells.At present, the relevant research results have been published online in the international academic journal American Chemical Society Nano. (Xinhua)