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monoallelic gene expression refers to the phenomenon in which all transcripts of a gene in the cells of a double organism come from an allele. The analysis of cell expression spectrum at the population level shows that the mutual inhibition between the imprint effect and allied genes is two possible mechanisms for the expression of monosethase genes. Since the analysis of population level may underestimate the prevalency of single-alleth gene expression in single-cell cells, the study of single-cell level can reveal the expression of single allied gene in cells more comprehensively.
the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences, a number of research groups with rice leaf meat cells as the object, co-research and reveal the existence of a wide range of monolithic gene expression in plants. The team applied single-cell transcription group dating techniques (single-cell RNA-seq) to plant cells and successfully obtained a single-cell expression spectrum of leaf meat cells from two rice subseeds (93-11 and Nipponbare) and their orthopaedic offspring (F1). The Qian Wenfeng and Wang Xiujie research group used single nucleotide polymorphisms between the 93-11 and Nipponbare subseeds to estimate the expression of two allied genes in F1 cells. By comparing the expression of allethan genes, the gene of single allethan gene expression in cells is defined. The results showed that about two-thirds of the genes in a single cell were expressed by a single allethan gene. Further research has found that the independence and randomness of alletic gene expression can explain the phenomenon of single allethic gene expression in cells. This study reveals the universality and possible mechanism of single allethic gene expression at the single-cell level, and lays a foundation for further study of the regulation and regulation of gene expression in cells.
the above findings were published online September 23, 2017 in
(DOI: 10.1016/j.scib.2017.09.011). Han Yingying, a ph.D. student who graduated from the Zhuo Yuling Research Group, and Chu Wei, a Ph.D. student from Qian Wenfeng Research Group, are co-authors of the article. Zhu Yuling and Qian Wenfeng are co-authors of this article. Researcher Wang Xiujie participated in the project cooperation. The study was funded by the Ministry of Science and Technology's 973 Project, the Central Group's "10,000 People Program" and the National Key Laboratory of Plant Genomics. (Source: Science.com)