Studies have revealed the mechanism of inflammatory response to fever-associated plateplate reduction syndrome

Xinhua News Agency, Wuhan, August 15 (Reporter Tan Yuanbin) A new study by Chinese researchers has revealed the inflammatory response mechanism of fever-related plateplate reduction syndrome, providing a theoretical reference for the development of its clinical treatment plan.
Reporters learned from China's
Wuhan Virus Research Institute on the 15th, the Institute's Peng Wei task force, Xiao Weifu task force and the military
Military Medical Research Institute Liu Wei team, through the use of clinical patient sample transcription group and quantitative protein group
histological methods, the study of the new disease-caused mechanism of the virus infection.
they found that the inflammatory response to plateast reduction syndrome associated with fever was highly associated with disease progression and fatal outcomes, while mitochondrial damage induced by the new type of transbugna virus infection may be associated with the occurrence of inflammatory responses. Further mechanism studies have revealed that the new type of transbugna virus infection induces oxidation of mitochondrial DNA, activates BAK/BAX to promote the release of mitochondrial DNA in the form of oxidation into the cytosome, and the mitochondrial DNA in the form of oxidation in cytosomes binds and activates the inflammatory small body of NLRP3, leading to disease-related inflammatory responses.
, it is known that fever-related plateplate reduction syndrome is a new viral infection that was first detected in China and spread in East Asia. The disease is caused by the new type of transmission of the unbonia virus infection, the disease is urgent, the clinical death rate is high, there is no vaccine.
the results of the study have recently been published online in the international academic journal Cell Communications.