Study found hundreds of genes that are prone to oncogenes

Using genetic expression data from multiple public sources, DrXingyi Guo, DrZhishan Chen, and colleagues systematically evaluated 294 GWAS-related variants for six types of cancer - colorectal cancer, lung cancer, ovarian cancer, prostate cancer, pancreatic cancer and melanomaimage source: American Journal of Human Geneticsthey identified 270 candidate-target genes, 99 of which had previously unreported correlationsCombined with the team's previous breast cancer data, there are at least two cancer types with 24 genesThe researchers found that 33 target genes were associated with specific mutation characteristics and 66 were associated with tumor mutation burdens in tumor tissueThe findings, publishedin American Journal of Human Genetics, deepen understanding of how risk variants identified by GWAS may promote cancer-causing: by regulating target susceptibility genes, which in turn promotes the production of somatic cell gene mutationsReferences: Zhishan Chen et alIdentifying Apping Genes and Evaluating Association Genes and Evaluating Association SIn Human Cancers, The American Journal of Human Genetics (2019)DOI: 10.1016/j.ajhg.2019.07.006