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On August 30, the international academic journal Toxic Sciences published online the latest research results of the Wu Aibo Research Group of the Shanghai Institute of Life Sciences (Institute of Nutrition and Health) of the Chinese Academy of Sciences, entitled "The Case of the Researcher son of the researcher sinofinos of cytotoxicity of cytotoxicity of the fung irium irium icomeotoxin in GES-1 cells", which found that vomit toxins (DON) exposed to human gastric mucosal epithelids (GES-1) minos.
of sickle toxin, especially vomit toxin (deoxygenated oxycodone knife sterol, DON), because of the pollution rate in various types of food, the average pollution of water is high, its safety limit standard set there are some controversy. How to carry out the evaluation of DON in vivo/in vitro toxicology more scientifically and accurately
has become a hot research topic in recent years.
Ph.D. student Yang Yunxia and other doctoral students based on the gag properties of DON toxin, the selection of the gastrointestinal system of human-derived cells GES-1 and DON toxin exposure interaction.
results show that DON exposure can induce oxidative stress, mitochondrial dysfunction, activation of ROS-JNK-FOXO3a signaling pathway, activated FOXO3a to play transcription regulation, affecting the cell's antioxidant, cycle block and apoptosis.
also verified the biological function of FOXO3a (contemporaries DAF16) with a pattern bionesis.
: The study of FOXO3a (fork head transcription factor O subtype), a key factor in the toxicity of the upper caricosis (GES-1) of the vomit toxin (DON) exposure to the human stomach mucosa epithelial cells (GES-1) and its response, provides a new way of thinking for the evaluation of mycotoxin safety using human-derived cells.
will further explore the potential of FOXO3a as a biomarker associated with DON toxicity through target animals (pigs, broilers).
the research was supported by the National Food Safety Key Research and Development Project, the National Natural Science Foundation of China, etc., and the strong support of the National Food Safety Risk Assessment Center, the Chinese Academy of Agricultural Sciences, the University of Ghent in Belgium, the University of Leeds in the United Kingdom, the University of Munster in Germany and other partners.
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