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    Home > Medical News > Medical Science News > Study on the clinical characteristics of neo-coronavirus disease

    Study on the clinical characteristics of neo-coronavirus disease

    • Last Update: 2020-12-30
    • Source: Internet
    • Author: User
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    February 28, led by Zhong Nanshan, head of the high-level expert group of the National Health Care Commission and a member of the Chinese Academy of Engineering, and Li Lanxuan, a member of the high-level expert group of the National Health Care Commission and a member of the Chinese Academy of Engineering, were officially published in the New England Journal of Medicine.
    analysis found that more than half of the patients were admitted to the hospital without fever, and 2.9% of the patients with severe illness and 17.9% of the non-severe patients did not find imaging abnormalities. At the same time, the situation of "super-transmitters" cannot be ruled out;
    given the rapid spread of the outbreak, the team, led by Zhong Nanshan, believes that an up-to-date analysis of cases across the country could help define the clinical characteristics and severity of the disease.researchers extracted laboratory-confirmed data on 1,099 new coronary pneumonia patients from 552 hospitals in 30 provinces, autonomous regions and municipalities directly under the central government. Data show that patients usually do not have fever performance, many patients do not have abnormal imaging performance.
    86.2% of chest CT scans showed abnormal results, most commonly in glass-grinding turbidity (56.4%) and double-sided patchy shadows (51.8%). Of the 877 non-severe patients, 17.9% did not find imaging or CT abnormalities, and in 5 of the 173 severe cases, no imaging or CT abnormalities were found.
    , the most common symptoms are fever and cough, nausea and vomiting, and diarrhea are rare. The medium incubation period for neo-crown pneumonia is 4 days. However, one patient in the severe and non-severe group had an incubation period of 24 days.
    addition, 23.7% of patients have at least one chronic disease (e.g. high blood pressure and chronic obstructive pulmonary disease).1099 cases, the patient's medium age was 47. Of these, 41.9 per cent were women, 0.9 per cent were under the age of 15 and 3.5 per cent were medical workers.
    researchers noted that 1.9 percent of patients had a history of exposure to wild animals and that there may be family aggregation outbreaks, asymptomatic patients spreading the disease, and three-stage outbreak patterns, and the presence of "super-transmitters" could not be ruled out.
    the study continues to confirm human-to-human transmission. In the study, 43.9 percent of the residents of Wuhan were residents of Wuhan, and 72.3 percent of non-Wuhan residents had contact with Wuhan, of which 31.3 percent had been to Wuhan. The rest have neither been to Wuhan nor been in contact with its residents.
    the paper, the medium hospital stay for all patients was 12 days. During hospitalization, the majority of patients were diagnosed with pneumonia by a physician, followed by acute respiratory distress syndrome and shock.
    the majority of patients (58.0%) received intravenous antibiotics, 35.8% received osethrave treatment, oxygen therapy accounted for 41.3% and mechanical aeration for 6.1%. At the same time, the proportion of mechanical breathing in severe patients was higher than in non-severe patients.the study's main composite endpoints were access to intensive care units (ICUs), mechanical aeration or death, indicators that had been used to assess the extent of other serious infectious diseases. The study found that a total of 67 patients had major compound endpoints, including 5.0% in the ICU, 2.3% in the acceptance of invasing mechanical aerence, and 1.4% of deaths.
    Zhong Nanshan and others said in their paper that the fatality rate from neo-coronary pneumonia was 1.4%, lower than previously reported, possibly due to differences in sample size and case inclusion criteria.
    researchers also found that while the new coronavirus and SARS coronavirus have genus similarities, some clinical features distinguish neocoopon pneumonia from SARS, MERS and seasonal influenza, such as seasonal influenza, which is more common in respiratory clinics and wards.
    addition, the researchers stressed that some patients with neo-coronary pneumonia did not have fever or imaging abnormalities at the time of their initial visit, which complicates the diagnosis.
    : "There is an urgent need to clarify the dynamic characteristics of virus transmission, transmission routes, virus addiction to human tissue." Studies have predicted the change trend of china's new crown pneumonia epidemic, but it has not been properly included in the government's recent interventions in various places, the national resumption of work, Wuhan and Huanggang and other places to seal the city on the change trend of the population epidemic. Therefore, the construction and validation of intelligent predictive models of virus transmission in the population is also the focus of the current work.
    relevant paper information:
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