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Acinetobacterbaumannii is a Grameen-negative bacteria widely present in the environment.
drug-resistant Baumannamy has become a major epidemic in hospitals, and is highly infectious and pathogenic to people with low immunity.
Bowman's immobility can cause pneumonia, urinary tract infections, blood-like infections, but also the main cause of burn infections.
Baumann's monobacteria, which have broad-spectrum resistance to a wide range of antibiotics, including carbon penicillin and mucosin, worldwide, rankfirst no. 1 - severely resistant, and all-drug-resistant Baumannaitus will likely evolve into "superbugs" that are increasingly difficult to target.
recently, Qi Xiaopeng of Kunming Institute of Zoology of the Chinese Academy of Sciences studied the mechanism of the i interferon signaling pathway in the regulation of the death of host cells induced by Baumann's immobility infection.
Infection syllavirus can cause host-produced apoptosis and inflammatory death - cell carophoresm and cell necrosis.
Baumann's cell-free infection induces the production of type I interferon through the signaling pathways of TRIF dependence, and the type I interferon is modified by KAT2B and P300 mediated H3K27ac histones, thus regulating the expression of the key genes of cell death, Zbp1, Mlkl, caspase-11 and Gsdmd, and promoting the death of GSDMD-mediated cells.
research published in Cell Death and TheS.
research work has been supported by the National Key Research and Development Program, the National Natural Science Foundation, the Chinese Academy of Sciences and the key laboratories of bioactive peptides in Yunnan Province.
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