Study on the mechanism of early embryonic development regulation in humans: Macaque VS mice.

Recently, the Chinese Academy of Sciences Kunming Animal Institute Zheng Ping group and the Chinese Academy of Sciences Mapu Computing Institute Han Jingdong task force, the study revealed that non-human primates (such as macaques) smaller mice are more suitable for the study of early human embryonic development control mechanism.
the results were published online in Genomics Research.
earlier embryos known to be primates had higher rates of chromosomal abnormalities and embryonic development failure than mice, but the mechanism was not clear.
researchers mapped the first gene expression of embryonic development at different stages before the macaques went to bed, and the work found a maternal gene and regulatory network that could regulate the reprogramming of the macaque embryonic hemologous genome and the activation of the hemologous genome.
And, through systematic comparison and analysis of mouse, macaque and human egg cells and early embryo development expression spectrum data, combined with functional verification, it is revealed that primate (monkey and human) eggs and early embryos to maintain the stability of genetic material is significantly lower than that of mice, the differences are mainly reflected in the activation of DNA damage response pathways and DNA entogenous recombination mediated damage repair pathways.
study also explains the high chromosomal instability and low rate of developmental success in early human and non-human primate embryos.
Finally, the study also points out the inherent reasons why precision gene replacement is extremely inefficient in monkeys using CRISPR/Cas9 technology and DNA iso-recombination principle, and suggests that the ability of iso-recombination can be enhanced by the introduction of recombinant enzymes in cell combination, which is expected to improve the efficiency of precision gene tapping in monkeys.
Extended reading: Chinese macaques are the study of the ideal animal model of immune aging reporters from the Kunming Institute of Zoology of the Chinese Academy of Sciences learned that the institute's doctoral student Zheng Hongyi under the guidance of researcher Zheng Yongtang found that Chinese macaques are more ideal for human immuno-aging-related research animal models, but also to study the role of gender-related factors on the immune system regulation of important models.
results were published recently in Experimental Gerontology.
researchers believe that macaques, as non-human primates, have a genetic background and biological characteristics that are closer to humans, and thus have a more direct advantage in aging-related studies than rodent models such as mice.
studies using Indian macaques as experimental animals have shown that their immune aging, although similar to that of humans, does not do a good job of simulating changes in human immune aging.
, there is a lack of suitable animal models to study the mechanisms associated with immune aging.
"We found that the rapid development of immune aging in Chinese macaques, 15-year-old Chinese macaques have the same degree of immune aging as the elderly over 60 years of age, than Indian macaques closer to the characteristics of human development."
," Zheng Hongyi said.
What's more interesting is that there are significant gender differences in immune aging in Chinese macaques, and the immune aging rate of male individuals is significantly faster than that of female individuals, resulting in the espresso of immune risk in older male Chinese macaques, but there is no significant correlation between immune aging and sex hormones in older male Chinese macaques.
is also commonly found in the human population and is thought to be a major cause of women living longer than men, while Indian macaques have not.
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