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    Home > Biochemistry News > Plant Extracts News > Study on the mechanism of green tea extract as neurotoxic inhibitor

    Study on the mechanism of green tea extract as neurotoxic inhibitor

    • Last Update: 2017-10-16
    • Source: Internet
    • Author: User
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    The study, carried out by McMaster University in Canada, revealed a potential mechanism by which green tea is beneficial to the brain The antioxidative and detoxifying properties of green tea extract help to fight such catastrophic diseases as Alzheimer's disease However, scientists have not fully understood their role at the molecular level and how to use them to find better treatments Preclinical evidence suggests that the main component of green tea polyphenols, known as EGCG (epigallocatechin gallate), can interfere with the assembly and formation of toxic oligomers in the brain of Alzheimer's patients In the early stages of the molecular cascade, this is one of the important factors leading to the decline of patients' cognitive ability Professor Giuseppe melacini explained that they believed that EGCG could encapsulate toxic oligomers and prevent them from developing and interacting with healthy cells However, the molecular mechanism of EGCG induction is not completely clear The effects of EGCG on β - amyloid oligomers were studied by combining 15N and 1H dark state exchange saturated transfer (dest), a new method of NMR, fluorescence chemical shift projection NMR, dynamic light scattering and electron microscopy They found that when combined with EGCG, the structure of a β (1 – 40) changed a lot These obvious structural changes provide a basis for understanding the molecular mechanism of why EGCG is a neurotoxic inhibitor The discovery is the result of the development of nuclear magnetic resonance (NMR) methods, and also reflects the effectiveness of the new dest based NMR method in the discovery of low molecular weight amyloid inhibitors, the researchers said The discovery, published on the cover of a top Chemical Journal, could lead to new treatments and further drug discovery In practice, there are still problems to be solved Once symptoms appear, Alzheimer's disease cannot be cured, so it is better to be able to carry out early intervention This may mean that green tea extract or its derivatives can be used 15 to 25 years before the disease occurs without any symptoms Next, the researchers hope to solve some practical problems, such as how to modify EGCG and similar molecules, so that they can be effectively used as food additives EGCG is unstable at room temperature and is known to be difficult to enter the human body, especially the brain Professor melacini said: "food additives may be a key or adjuvant treatment In addition to exercise and a healthy lifestyle, it's important to take advantage of the value of food additives when you're young to increase your chances of healthy aging " Reference 1) molecular mechanism for the (−) - epigalacatechin gallate induced toxic to nontoxic remoting of a β olympics 2) green tea extract deliveries molecular punch to disrupt formation of neurotic specialties
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