Study on the mechanism of ultrasonic nerve regulation: the preparation of a new type of ultrasonic nerve stimulation chip and regulatory device was successful.

Recently, Zheng Hairong's team at the Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences made new progress in ultrasound nerve regulation.
the results of the study, Ultrasound neuro-modulation chip: activation of sensory neurons in Caenhabditis elegans by surface acoustic waves published in lab on a chip magazine, and selected as the cover article of the current issue.
recent years, neuropsychiatic diseases have been widespread, and the use of physical methods to regulate specific nuclear groups is a practical way to treat and intervene in neuropsychiatic diseases.
as a mechanical wave, ultrasound can stimulate the deep brain region of the skull without invasive stimulation, and as a non-invasive means of neuromodtic regulation has attracted more and more attention.
complex ultrasound physical effects, including mechanical effects, thermal effects, etc. , the mechanism of ultrasound nerve regulation is not clear.
researchers have designed and prepared a new type of ultrasonic nerve stimulation chip, with the classic model of the biologically beautiful cryptical nematode as the object of study.
results show that under the action of ultrasound, nebule multimode recepcess neuron ASH is activated by ultrasound, resulting in evasive behavioral response.
meanwhile, temperature-sensing AFD neurons are not activated by ultrasound, suggesting that nebule avoidance is mainly caused by ultrasonic mechanical effects, a result further validated by the Tax-4 mutant experiment.
The significance of this work lies in the introduction of a new type of ultrasonic nerve regulation device, which can be compatible with calcium imaging, diaphragm pliers and other biological means to achieve the study of ultrasonic nerve regulation mechanism, so as to provide a basis and theoretical basis for ultrasonic nerve regulation and treatment of neurological diseases.
the above-mentioned research work has been supported by the National Natural Science Foundation of China's national major scientific research equipment development projects, Guangdong Province Jieqing project and Shenzhen discipline layout and other projects.
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