Study on the mechanisms that induce these mechanical behaviors of skin stem cells.

Human skin is a remarkable organ that protects the body from pathogens, toxic substances and other harmful substances; of course, our skin needs to be continuously updated throughout the human life, while changing the size of the skin to accommodate the body's coverage and protection, in order to complete complex dynamic behavior, each cell in the skin has a specific task, depending on where it is located The density and congestion of cells play a key role in guiding the fate of a single stem cell and the movement of differentiated cells within the tissue, which may be able to ensure that all cell types are properly positioned within the tissue, according to a study published in the international journal Nature Cell Biology.
adult epidermis is composed of many layers, stem cells are located at the lowest level, the task is to produce new cells, and then differentiation and upward to move to a special skin layer to play a corresponding role, the differentiation process mainly includes permanent changes in cellular characteristics, to be most suitable for the skin's natural barrier function.
skin must maintain a balance between stem cell and differentiated cell levels, and the lack of balance can lead to abnormal structure and function, but researchers do not yet know the molecular mechanisms that maintain this complex balance.
researcher Yekaterina Miroshnikova said: 'From the beginning of the study, we wanted to figure out how the skin knows where it is and how it works; in this study, we analyzed embryonic mouse tissue and cultured stem cells to find mechanisms that induce these mechanical behaviors of the skin.
local pressure induced by crowding together promotes cell differentiation Researchers point out that divided stem cells induce a local crowding effect in the stem cell layer that induces cell deformation, and more interestingly, cell-to-cell extrusion and deformation induces differentiation in nearby cells, where crowded and squeezed cells can alter their own properties, escaping from local pressure at the bottom and moving upward.
actually, these cells are able to sense changes in the behavior of the cells near them, which may provide researchers with an effective and simple way to help maintain tissue size, structure, and function.
the results of this paper for the first time, complex body tissues such as human skin are produced and maintained by simple self-organizing principles, and future researchers will continue to combine computer models with cell biology techniques to illustrate how specific genetic mutations during cancer target the proliferation of stem cells and how to develop effective means to kill cancer cells.
.