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    Home > Biochemistry News > Biotechnology News > Study on the origin and evolutionary mechanism of H5N6 avian influenza virus.

    Study on the origin and evolutionary mechanism of H5N6 avian influenza virus.

    • Last Update: 2020-09-14
    • Source: Internet
    • Author: User
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    Since human infection with the H5N6 influenza virus was first reported in 2014, H5N6 has been endemic in poultry in China and Southeast Asian countries, and human infection cases continue to occur.
    H5N6 as a new influenza virus, its genetic origin, evolutionary mechanism and epidemic trends are not yet systematic and in-depth research.
    The Influenza Research and Early Warning Center of the Chinese Academy of Sciences, under the leadership of Gao Fu, a member of the Chinese Academy of Sciences, has been continuously monitoring the avian influenza virus epidemic in 16 provinces and 39 cities and counties in 16 provinces and regions of China since 2014 through the Key Laboratory of Pathogenic Microbiology and Immunology of the Institute of Microbiology of the Chinese Academy of Sciences, in close cooperation with the Wuhan Virus Research Institute of the Chinese Academy of Sciences, the Third People's Hospital of Shenzhen, Taishan Medical College, Jilin University, Fujian Academy of Agriculture and Forgology.
    monitoring data show that the northern region of China is mainly H9N2, the Yangtze River Delta, central and southern China have a certain proportion of H7N9, and the proportion of H5N6 south of the Yangtze River Delta region increased, gradually replacing H5N1 as the dominant epidemic strain.
    correlation between the virus and the host showed that H5N6 and H6N6 were the main virus subtypes prevalent in ducks, while H9N2 was the main prevalence in chickens.
    ducks play an important role in the production and spread of H5N6.
    further genetic origin and genetic evolution analysis of the H5N6 avian influenza virus shows that H5N6 originated from the mate of H5Ny and H6N6; Genes are constantly matched with low pathogenic avian influenza viruses during the epidemic and spread of the virus, forming at least 34 genotypes and naturally screening out four dominant genotypes (G1, G2, G1.1, G1.2).
    G1 and G2 are the earliest genotypes, G1.1 is a PB2 gene for the H6 virus based on G1, and the G1.2 internal gene is derived from H9N2/H7N9.
    viruses that currently infect people belong to these four genotypes.
    note that G1.2 is similar to the H7N9 and H10N8 virus genomics and causes at least five human infections.
    people are mainly infected through direct contact with poisonous birds or pollutants, has not yet achieved human-to-human transmission, while the H5N6 virus has been isolated in pigs, cats, wild birds found.
    H5N6 infection of poultry, wild birds, mammals and humans is a wake-up call to us that active and effective prevention and control measures must be taken to prevent the spread of the virus in poultry from continuing to expand, thereby reducing the risk of human infection.
    the study reveals the evolutionary law and epidemic trend of H5N6 virus, which is of guiding significance to the prevention and control of avian influenza in China and the world.
    results were published online on December 1st in the international academic journal Cell Host and Microbe.
    The Chinese Academy of Sciences influenza research and early warning center, microbiology institute influenza technology platform leader Bi Yuhai as the first author, Wuhan virus Chen Quanxuan, microbiology wang Qianli, Wuhan virus Chen Jianjun as the first author.
    Gaofu is the core correspondent, Liu Weifeng, a researcher at the Institute of Microbiology of the Chinese Academy of Sciences, Shi Weifeng, a professor at Taishan Medical College, and Liu Yingxia, a professor at the Third People's Hospital in Shenzhen, are the co-authors of the newsletter.
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