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It is well known that wound healing is related to age, young or young adults, that recovery is fast, and the reverse is slow.
's why? A study in the latest issue of Cell solves this mystery.
November 17th, Cell published a Rockefeller University experiment examining molecular changes in the skin of aging mice and describing the process by which the body heals wounds.
Elaine Fuchs, a professor of cell biology at Rockefeller University and a researcher at the Howard Hughes Institute of Medicine, said that within days of injury, skin cells migrate and close wounds, a process that involves coordinating nearby immune cells.
their experiments suggest that communication between skin and immune cells is gradually disrupted as we age, a finding that could shed new forms of accelerated treatment for older people.
every time a wound occurs, the body needs to quickly repair the protective function of the skin barrier, and wound healing is one of the most complex processes that occurs in the body.
Many types of cells, analytical paths, and signaling systems require overtime from seconds to months to cope with changes, with skin cells and immune cells contributing from healing to knots, and new skin cells growing as the horned cells become moles on the wound.
the team focused on two to 24-month-old mice, the equivalent of humans between the ages of 20 and 70.
found that older mice's horned cells migrate slowly, so that wounds recover slowly.
why do older mice's horned cells migrate slowly? It turns out that wound healing requires specific immune cells present in the skin.
In the image above, after the injury, the cells at the edge of the wound fill the gap by producing a protein called Skint that awakens nearby immune cells, including dextical endocrine T cells, DETCs;
to see if it could improve the ability of older people to produce "Skint" proteins, researchers turned to raw "Skint" proteins.
When they put the protein in the young mice and the skin tissue of the elderly mice in a petri dish, they saw faster cell migration, so scientists hope to use this principle to develop products that accelerate the healing of old wounds, and even to develop drug activation pathways based on immune cells.
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