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    Home > Biochemistry News > Biotechnology News > Study reveals how blood vessels use 'shortcuts' to control cardiovascular system

    Study reveals how blood vessels use 'shortcuts' to control cardiovascular system

    • Last Update: 2022-05-08
    • Source: Internet
    • Author: User
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    Cardiovascular disease is a group of diseases caused by physical inactivity, poor diet, or certain medical conditions
    .
    Scientists already knew that these diseases start with changes in the endothelial cells of blood vessels

    .
    But why and how endothelial cell function changes is not fully understood

    .

    A new study led by the Centre for Vascular Imaging at the University of Strathclyde shows that these cells use a complex system to communicate with each other
    .
    The failure of this communication system may be the first step in the development of cardiovascular disease

    .

    The endothelium is the thin lining of cells within blood vessels that regulates blood flow, blood pressure, blood clotting, inflammation and the response to disease
    .
    It constantly processes the vast amount of information stored in the blood components and chemicals in the area around each blood vessel to keep the cardiovascular system working properly

    .

    Research from the University of Strathclyde has found that endothelial cells have clusters of cells that have specific functions and operate in clusters
    .
    Between cliques, there are many interconnected connections to pass information, and a high density of connections to protect the system from communication failures

    .
    The system transmits information quickly over distance by using shortcuts to bypass neighboring cells

    .

    The findings suggest that the endothelial communication network is designed to be similar to the communication operation of the Internet, which can effectively control local blood vessels and improve overall efficiency in determining overall cardiovascular activity
    .
    The design is robust so that the communication system controlling cardiovascular activity does not fail even with extensive damage

    .

    The findings also suggest that the disease may be based on changes in communicating tissues, rather than the behavior and function of individual cells
    .

    The researchers addressed the nature of communication networks by using single-cell calcium imaging on thousands of intact vascular endothelial cells and applying mathematical network (graph) theory
    .
    The research, conducted in conjunction with the Karolinska Institutet in Stockholm, has been published in the Proceedings of the National Academy of Sciences

    .

    Professor John McCarran, from the Strathclyde Institute for Pharmaceutical and Biomedical Research, said: "Endothelial cells are a major target in the control of cardiovascular disease and are often seen as a unified cell population
    .
    Our findings suggest that these Cells are not uniform, but specialized for a specific type of function

    .
    "

    "Having a well-organized, fast and robust communication system that shares information for a coordinated response
    .
    Communication systems provide new targets for treatment development and insight into why developing treatments has proven so difficult

    .
    "


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