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Recently, a research result published by the Séverine Sabia team at the University of Paris in France is about to pierce the hearts of middle-aged people.
They analyzed the 25-year research data of nearly 10,000 people and found that the short sleep time of middle-aged people is related to the increased risk of dementia after old age.
Specifically, compared with people who sleep between 6 hours and 14 minutes to 7 hours a night, less than this sleep time is associated with a 63% increase in the risk of dementia [1].
The research results were published in the well-known journal "Nature Communications".
Middle-aged people, it's time to pay attention to their sleep quality.
Screenshot of the paper's homepage Sleep is very important to human health.
We sleep for about one-third of our lives.
Reports from the American Academy of Sleep Medicine and the Society for Sleep Research recommend that adults between the ages of 18 and 60 get at least 7 hours of sleep per night [2].
I wonder if the readers of Singularity Cake have reached the standard? When it comes to the hazards of insufficient sleep, I believe everyone can immediately think of a lot, such as increasing the risk of obesity, diabetes and cardiovascular disease [3].
In addition to increasing the risk of chronic non-communicable diseases mentioned above, more and more research evidence shows that too short or too long sleep time may be related to the onset of some neurodegenerative diseases such as dementia [4].
However, due to the fact that the baseline age of participants included in most relevant studies is 65 years or older, the relationship between sleep time and the onset of dementia in later life in the middle-aged population (50 years of age) is currently unclear.
Professor Séverine Sabia and colleagues want to explore the above questions.
The prospective cohort study they used included 10,308 British civil servants between the ages of 35 and 55 at the baseline (1985-1988), followed by follow-up every 4 to 5 years to collect relevant clinical data.
The study ended on March 31, 2019, and a total of 5 follow-up data were obtained (1997-1999, 2002-2004, 2007-2009, 2012-2013, 2015-2016).
Based on pre-set inclusion and exclusion criteria, the researchers included 7,959, 7,164, and 6,516 study subjects in the 50, 60, and 70-year-old age groups (±5 years) for analysis.
In the study, the researchers divided the participants' self-reported sleep time into three categories: too short sleep time (less than or equal to 6 hours), normal sleep time (about 7 hours), and too long sleep time (greater than or equal to 8 hours) .
Dementia cases are determined by linking three national registration systems.
The study process ended at the end of the study.
The study population of 50, 60, and 70 years old had an average follow-up time of 24.
6, 14.
8, and 7.
5 years, respectively.
In the Cox regression model that only adjusted for sociodemographic factors, researchers found that shorter sleep time was associated with a higher risk of dementia in the study population of all ages.
After adjusting for behavioral and health-related factors in the above model, the researchers only found that in the study population of 50 and 60 years old, compared with participants who slept for about 7 hours, the daily sleep time was less than or equal to 6 Hours are associated with a 22% and 37% increase in the risk of dementia.
The results of the multivariate model show that insufficient sleep time is an independent risk factor for dementia.
In this study, 6875 subjects survived at the age of 70 and did not suffer from dementia, and had at least 2 sleep time data.
After an average follow-up time of 7.
4 years in this sub-cohort, 426 persons were diagnosed with dementia.
Based on the sleep time data of this sub-cohort, the researchers determined the trajectories of six types of sleep time changes, including continuous short-term sleep, continuous normal sleep time, continuous long-term sleep, transition from short-term sleep to normal sleep, and From normal sleep to long-term sleep and from normal sleep to short-term sleep.
A study on the trajectory of sleep time changes found that compared with the study population who continued to maintain a normal sleep time, continued short-term sleep was associated with a 30% increase in the risk of dementia.
The risk of dementia is still significantly increased in those who continue to sleep for a short period of time.
Subsequently, the researchers conducted a separate analysis of participants who had no history of mental illness before the age of 65 and found that in the three research age groups, the shorter sleep time was the same as It is associated with an increased risk of dementia in the future.
In order to explore the impact of measurement errors caused by self-reported sleep time on the results of the study, the researchers conducted a separate analysis of 3888 participants whose sleep time was accurately estimated and found that the sleep time per night was between 6 hours and 14 minutes to 7 hours.
Compared with the population, sleep less than that is associated with a 63% higher risk of dementia.
It is worth noting that the study did not find an association between excessive sleep time or sustained long sleep and the risk of dementia.
Participants who use algorithms to objectively estimate sleep time are associated with too short sleep time and increased risk of dementia.
Finally, the researchers conducted a sensitivity analysis based on the inverse probability-weighted analysis method to consider the impact of missing data on the research conclusions.
These supporting evidence The results of the analysis are generally consistent with the main research results.
In general, the study found through a series of analyses that insufficient sleep time in middle-aged people is associated with an increased risk of subsequent dementia, and this association is independent of sociodemographic factors, behavioral factors, cardiometabolic and mental health factors.
However, the researchers did not observe any dangerous effects related to excessive sleep time or sustained long-term sleep, which is different from the general "U"-shaped relationship between sleep duration and health outcomes.
In the discussion section, the author pointed out that in the process of including the study subjects, the selected participants were healthier than the general population, so the extrapolation of the research conclusions was limited to a certain extent.
In addition, due to the inherent characteristics of observational research, the author cannot completely exclude the influence of some potential confounding factors that are not included in the multi-factor model on the research conclusions.
Because dementia has a high prevalence in the elderly, and this type of disease has a huge impact on the family and society, the identification of risk factors for this type of disease has important public health significance.
In general, while encouraging young people to improve their sleep conditions, we should also pay equal attention to the sleep time and sleep quality of middle-aged and elderly people.
(I hope the teacher will assign less homework, so that the children and parents can go to bed earlier) Reference materials: [1].
Sabia S, Fayosse A, Dumurgier J, et al.
Association of sleep duration in middle and old age with incidence of dementia .
Nat Commun.
2021;12(1):2289.
doi:10.
1038/s41467-021-22354-2[2].
Consensus Conference Panel, Watson NF, Badr MS, et al.
Joint Consensus Statement of the American Academy of Sleep Medicine and Sleep Research Society on the Recommended Amount of Sleep for a Healthy Adult: Methodology and Discussion.
Sleep.
2015;38(8):1161-1183.
doi:10.
5665/sleep.
4886[3].
Liu Y, Wheaton AG, Chapman DP, Cunningham TJ, Lu H, Croft JB.
Prevalence of Healthy Sleep Duration among Adults--United States, 2014.
MMWR Morb Mortal Wkly Rep.
2016;65(6):137-141.
doi:10.
15585/mmwr.
mm6506a1 [4].
Fan L, Xu W, Cai Y, Hu Y, Wu C.
Sleep Duration and the Risk of Dementia:A Systematic Review and Meta-analysis of Prospective Cohort Studies.
J Am Med Dir Assoc.
2019;20(12):1480-1487.
e5.
doi:10.
1016/j.
jamda.
2019.
06.
009 Responsible EditorBioTalker
They analyzed the 25-year research data of nearly 10,000 people and found that the short sleep time of middle-aged people is related to the increased risk of dementia after old age.
Specifically, compared with people who sleep between 6 hours and 14 minutes to 7 hours a night, less than this sleep time is associated with a 63% increase in the risk of dementia [1].
The research results were published in the well-known journal "Nature Communications".
Middle-aged people, it's time to pay attention to their sleep quality.
Screenshot of the paper's homepage Sleep is very important to human health.
We sleep for about one-third of our lives.
Reports from the American Academy of Sleep Medicine and the Society for Sleep Research recommend that adults between the ages of 18 and 60 get at least 7 hours of sleep per night [2].
I wonder if the readers of Singularity Cake have reached the standard? When it comes to the hazards of insufficient sleep, I believe everyone can immediately think of a lot, such as increasing the risk of obesity, diabetes and cardiovascular disease [3].
In addition to increasing the risk of chronic non-communicable diseases mentioned above, more and more research evidence shows that too short or too long sleep time may be related to the onset of some neurodegenerative diseases such as dementia [4].
However, due to the fact that the baseline age of participants included in most relevant studies is 65 years or older, the relationship between sleep time and the onset of dementia in later life in the middle-aged population (50 years of age) is currently unclear.
Professor Séverine Sabia and colleagues want to explore the above questions.
The prospective cohort study they used included 10,308 British civil servants between the ages of 35 and 55 at the baseline (1985-1988), followed by follow-up every 4 to 5 years to collect relevant clinical data.
The study ended on March 31, 2019, and a total of 5 follow-up data were obtained (1997-1999, 2002-2004, 2007-2009, 2012-2013, 2015-2016).
Based on pre-set inclusion and exclusion criteria, the researchers included 7,959, 7,164, and 6,516 study subjects in the 50, 60, and 70-year-old age groups (±5 years) for analysis.
In the study, the researchers divided the participants' self-reported sleep time into three categories: too short sleep time (less than or equal to 6 hours), normal sleep time (about 7 hours), and too long sleep time (greater than or equal to 8 hours) .
Dementia cases are determined by linking three national registration systems.
The study process ended at the end of the study.
The study population of 50, 60, and 70 years old had an average follow-up time of 24.
6, 14.
8, and 7.
5 years, respectively.
In the Cox regression model that only adjusted for sociodemographic factors, researchers found that shorter sleep time was associated with a higher risk of dementia in the study population of all ages.
After adjusting for behavioral and health-related factors in the above model, the researchers only found that in the study population of 50 and 60 years old, compared with participants who slept for about 7 hours, the daily sleep time was less than or equal to 6 Hours are associated with a 22% and 37% increase in the risk of dementia.
The results of the multivariate model show that insufficient sleep time is an independent risk factor for dementia.
In this study, 6875 subjects survived at the age of 70 and did not suffer from dementia, and had at least 2 sleep time data.
After an average follow-up time of 7.
4 years in this sub-cohort, 426 persons were diagnosed with dementia.
Based on the sleep time data of this sub-cohort, the researchers determined the trajectories of six types of sleep time changes, including continuous short-term sleep, continuous normal sleep time, continuous long-term sleep, transition from short-term sleep to normal sleep, and From normal sleep to long-term sleep and from normal sleep to short-term sleep.
A study on the trajectory of sleep time changes found that compared with the study population who continued to maintain a normal sleep time, continued short-term sleep was associated with a 30% increase in the risk of dementia.
The risk of dementia is still significantly increased in those who continue to sleep for a short period of time.
Subsequently, the researchers conducted a separate analysis of participants who had no history of mental illness before the age of 65 and found that in the three research age groups, the shorter sleep time was the same as It is associated with an increased risk of dementia in the future.
In order to explore the impact of measurement errors caused by self-reported sleep time on the results of the study, the researchers conducted a separate analysis of 3888 participants whose sleep time was accurately estimated and found that the sleep time per night was between 6 hours and 14 minutes to 7 hours.
Compared with the population, sleep less than that is associated with a 63% higher risk of dementia.
It is worth noting that the study did not find an association between excessive sleep time or sustained long sleep and the risk of dementia.
Participants who use algorithms to objectively estimate sleep time are associated with too short sleep time and increased risk of dementia.
Finally, the researchers conducted a sensitivity analysis based on the inverse probability-weighted analysis method to consider the impact of missing data on the research conclusions.
These supporting evidence The results of the analysis are generally consistent with the main research results.
In general, the study found through a series of analyses that insufficient sleep time in middle-aged people is associated with an increased risk of subsequent dementia, and this association is independent of sociodemographic factors, behavioral factors, cardiometabolic and mental health factors.
However, the researchers did not observe any dangerous effects related to excessive sleep time or sustained long-term sleep, which is different from the general "U"-shaped relationship between sleep duration and health outcomes.
In the discussion section, the author pointed out that in the process of including the study subjects, the selected participants were healthier than the general population, so the extrapolation of the research conclusions was limited to a certain extent.
In addition, due to the inherent characteristics of observational research, the author cannot completely exclude the influence of some potential confounding factors that are not included in the multi-factor model on the research conclusions.
Because dementia has a high prevalence in the elderly, and this type of disease has a huge impact on the family and society, the identification of risk factors for this type of disease has important public health significance.
In general, while encouraging young people to improve their sleep conditions, we should also pay equal attention to the sleep time and sleep quality of middle-aged and elderly people.
(I hope the teacher will assign less homework, so that the children and parents can go to bed earlier) Reference materials: [1].
Sabia S, Fayosse A, Dumurgier J, et al.
Association of sleep duration in middle and old age with incidence of dementia .
Nat Commun.
2021;12(1):2289.
doi:10.
1038/s41467-021-22354-2[2].
Consensus Conference Panel, Watson NF, Badr MS, et al.
Joint Consensus Statement of the American Academy of Sleep Medicine and Sleep Research Society on the Recommended Amount of Sleep for a Healthy Adult: Methodology and Discussion.
Sleep.
2015;38(8):1161-1183.
doi:10.
5665/sleep.
4886[3].
Liu Y, Wheaton AG, Chapman DP, Cunningham TJ, Lu H, Croft JB.
Prevalence of Healthy Sleep Duration among Adults--United States, 2014.
MMWR Morb Mortal Wkly Rep.
2016;65(6):137-141.
doi:10.
15585/mmwr.
mm6506a1 [4].
Fan L, Xu W, Cai Y, Hu Y, Wu C.
Sleep Duration and the Risk of Dementia:A Systematic Review and Meta-analysis of Prospective Cohort Studies.
J Am Med Dir Assoc.
2019;20(12):1480-1487.
e5.
doi:10.
1016/j.
jamda.
2019.
06.
009 Responsible EditorBioTalker
