Sub-Journal of "Science": Can low hemoglobin prevent obesity?

Obesity and metabolic syndrome are major health problems worldwide and are associated with many comorbidities and premature death
.

Half of Finnish adults are overweight, a quarter have metabolic syndrome, and childhood obesity is also increasing.

Lower levels of hemoglobin may prevent obesity and metabolic syndrome Lower levels of hemoglobin may prevent obesity and metabolic syndrome

Recently, research published in "Science Advances" shows that individual differences in hemoglobin levels are closely related to metabolic health in adulthood
.

Hemoglobin levels are related to body mass index, blood lipids, and blood pressure.

Hemoglobin levels are related to body mass index, blood lipids, and blood pressure.

Juha Auvinen et al, Systematic evaluation of the association between hemoglobin levels and metabolic profile implicates beneficial effects of hypoxia, Science Advances (2021).
DOI: 10.
1126/sciadv.
abi4822

Juha Auvinen et al, Systematic evaluation of the association between hemoglobin levels and metabolic profile implicates beneficial effects of hypoxia, Science Advances (2021).
DOI: 10.
1126/sciadv.
abi4822

The researchers first assessed the relationship between the hemoglobin level of C57Bl/6 mice and key metabolic parameters, and found that there was a positive correlation between the hemoglobin level and body weight of the mice at the age of 1 year
.

When observing the relationship between lower hemoglobin levels and glucose tolerance and insulin resistance, it was found that hemoglobin levels may affect metabolic health

It was found that there was a positive correlation between the hemoglobin level and body weight of the mice at the age of 1 year

Association of hemoglobin level with body weight, glucose tolerance and insulin resistance in mice

Association of hemoglobin level with body weight, glucose tolerance and insulin resistance in mice

The lower levels of hemoglobin observed in the study are related to a mild hypoxia and activated HIF response in the body
.

Mild hypoxia activates the HIF response, which may prevent obesity and adverse metabolism

The lower levels of hemoglobin observed in the study are related to a mild hypoxia and activated HIF response in the body

How to reduce the body's oxidation level to achieve permanent activation of the HIF response, thereby protecting people from obesity? The HIF enzyme that causes hypoxia may be used as a target for human obesity and metabolic drugs
.

Currently in Asia, they are used to treat renal anemia

There is a positive correlation between the hemoglobin level and body mass index of 46-year-old men and women

There is a positive correlation between the hemoglobin level and body mass index of 46-year-old men and women.
There is a positive correlation between the hemoglobin level and body mass index of 46-year-old men and women.

This positive association was also verified in a 42-year-old population in the Finnish Youth Cardiovascular Risk Study.
The hemoglobin increased by 10 g/l and the BMI increased by 3.
5%.
That is, in an individual with a BMI of 25.
0 kg/m ² , the BMI increased To 25.
9kg/m ²
.

Hemoglobin level is also positively correlated with waist circumference, hip circumference, waist-to-hip ratio, body fat percentage and visceral fat area, and negatively correlated with body muscle mass ratio

Hemoglobin increased by 10 g/L, BMI increased by 3.

In addition, hemoglobin levels and the concentration and size of lipoprotein subclass particles, apolipoproteins, triglycerides, cholesterol, fatty acids (FAs), lactic acid, glycerol, branched chain amino acids, aromatic amino acids, inflammatory glycoprotein acetylation, and creatinine were also found There is a correlation between the levels of albumin and ketone bodies
.

In animal experiments, the hemoglobin level of C57Bl/6 mice was manipulated by phlebotomy, followed by physiological induction of erythropoiesis
.
The data showed that within 2 weeks, erythropoiesis induced by venous incision increased the hemoglobin level of mice, and increased body weight and fasting blood glucose, total cholesterol, low-density lipoprotein + low-density lipoprotein cholesterol and lactic acid levels, which were weak The evidence suggests an increase in the insulin resistance index
.

Original source:

Juha Auvinen et al, Systematic evaluation of the association between hemoglobin levels and metabolic profile implicates beneficial effects of hypoxia, Science Advances (2021).
DOI: 10.
1126/sciadv.
abi4822

Juha Auvinen et al, Systematic evaluation of the association between hemoglobin levels and metabolic profile implicates beneficial effects of hypoxia, Science Advances (2021) DOI:.
10.
1126 / sciadv.
abi4822 in this message