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*For medical professionals
only, what's going on?
before the diagnosis of mild cognitive impairment (MCI).
Study screenshots
prior to MCI and dementia events.
.
Annual follow-up (maximum follow-up 22 years)
was conducted from October 1997 to December 2020.
During the follow-up visit, some participants underwent brain autopsies (cadavers).
It turned out that:
Our findings suggest that high levels of Alzheimer's disease pathology or cerebrovascular disease pathology may be associated with
a decrease in BMI prior to MCI.
Future imaging studies (e.
g.
, using positron emission tomography) are necessary to elucidate the temporal association
between BMI changes and brain pathology.
only, what's going on?
Executive Summary
before the diagnosis of mild cognitive impairment (MCI).
Study screenshots
status quo
prior to MCI and dementia events.
conclusion
.
Annual follow-up (maximum follow-up 22 years)
was conducted from October 1997 to December 2020.
During the follow-up visit, some participants underwent brain autopsies (cadavers).
It turned out that:
- In the BMI trajectory analysis before MCI (n=939), a total of 371 participants (39.
5%) developed MCI during follow-up, of which 88 (23.
7%) developed dementia
. - Patients with MCI were older [mean (SD) age, 79.
6 (5.
9) years vs 76.
9 (6.
6) years], consumed less alcohol, had a lower BMI, and were mostly ε4 carriers
. - Patients with dementia were older [mean (SD) age, 81.
0 (5.
2) years versus 79.
1 (6.
0 years)], had lower levels of physical activity [median (IQR) activity, 1.
0 h/week to 1.
8 h/week], and were more likely to be APOEε4 carriers than those without dementia
. - In participants who developed MCI, BMI tended to decline
earlier and faster compared to cognitively intact participants. - From 7 years before diagnosis, BMI was significantly reduced
in patients with MCI. - In people who developed MCI, the slope of BMI decline did not differ significantly between those who developed and those who did not develop dementia
. - In pre-autopsy BMI trajectory analysis (n=358), rapid decline in BMI was associated with
participants at high risk of Alzheimer's disease pathology worldwide.
prospect
Our findings suggest that high levels of Alzheimer's disease pathology or cerebrovascular disease pathology may be associated with
a decrease in BMI prior to MCI.
Future imaging studies (e.
g.
, using positron emission tomography) are necessary to elucidate the temporal association
between BMI changes and brain pathology.
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