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    Home > Active Ingredient News > Antitumor Therapy > Sugar-free ≠ healthy!

    Sugar-free ≠ healthy!

    • Last Update: 2022-04-23
    • Source: Internet
    • Author: User
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    People with higher intakes of artificial sweeteners, especially aspartame and acesulfame potassium, had a higher risk of developing cancer over an eight -year period compared to people who never used artificial sweeteners, new research suggests.
    13% higher .
    On March 24 , the results of the observational study from the French research team were published online in PLOS MEDICINE under the title "Artificial sweeteners and cancer risk: Results from the NutriNet-Santé population-based cohort study" .
    The study showed that an increased intake of aspartame was associated with a 22% increased risk of overall cancer and a 15% increased risk of obesity-related cancers , compared with no artificial sweeteners .

    People with higher intakes of artificial sweeteners, especially aspartame and acesulfame potassium, had a higher risk of developing cancer over an eight -year period compared to people who never used artificial sweeteners, new research suggests.


    13% higher .
    On March 24 , the results of the observational study from the French research team were published online in PLOS MEDICINE under the title "Artificial sweeteners and cancer risk: Results from the NutriNet-Santé population-based cohort study" .
    The study showed that an increased intake of aspartame was associated with a 22% increased risk of overall cancer and a 15% increased risk of obesity-related cancers , compared with no artificial sweeteners .

    Figure 1 Research results (Source: PLOS MEDICINE )

    Figure 1 Research results (Source: PLOS MEDICINE )

    In this study, researchers followed 102,865 adults from NutriNet-Santé , France ( 2009-2021 ) with 24 -hour dietary records for dietary intake and consumption of artificial sweeteners, adjusted for age Cox proportional hazards model was used to evaluate the association between artificial sweeteners and the incidence of cancer after related factors such as gender, education level, medical history, and life>.


    The study found that the intake of artificial sweeteners increased the overall risk of cancer by 13% , including a 22% increase in the risk of breast cancer and a 15% increase in the risk of " obesity-related " cancers such as stomach , liver, colon and rectal cancers .

    In this study, researchers followed 102,865 adults from NutriNet-Santé , France ( 2009-2021 ) with 24 -hour dietary records for dietary intake and consumption of artificial sweeteners, adjusted for age Cox proportional hazards model was used to evaluate the association between artificial sweeteners and the incidence of cancer after related factors such as gender, education level, medical history, and life>.
    The study found that the intake of artificial sweeteners increases the overall risk of cancer in the human body by 13 % , including a 22% increase in the risk of breast cancer , and " obesity-related " cancers such as gastric , liver, colon and rectal cancers .
    15% increased risk .

    Figure 2 Associations between total artificial sweeteners, aspartame, acesulfame potassium, and sucralose intake and cancer risk (Image source: PLOS MEDICINE ) 

    Figure 2 Associations between total artificial sweeteners, aspartame, acesulfame potassium, and sucralose intake and cancer risk (Image source: PLOS MEDICINE ) 

    These findings suggest that artificial sweeteners may be a modifiable risk factor for cancer prevention and provide new information for the global health agency's reassessment of the safety of food additives, artificial sweeteners
    .


    The new findings do not support the use of artificial sweeteners as a substitute for sugar in food or beverages and need to be confirmed by larger studies in the future


    These findings suggest that artificial sweeteners may be a modifiable risk factor for cancer prevention and provide new information for the global health agency's reassessment of the safety of food additives, artificial sweeteners


    It is worth mentioning that the toxicity of the artificial sweetener aspartame has been confirmed in several earlier in vitro studies, which have shown that it is carcinogenic, possibly through its interaction with inflammation, angiogenesis , promotion of vascular DNA damage and inhibition of cells.
    Apoptosis and other related mechanisms promote the development of cancer


    In addition, a study published in the International Journal of Molecular Science also showed that some widely used artificial sweeteners (saccharin, sucralose and aspartame) can change the flora ecology of Escherichia coli and Enterobacter faecalis by altering the , which in turn alters the gut microbiota (inducing dysbiosis and glucose intolerance in mice and healthy humans), leading to disease in humans


    Figure 3 Research results (Source: International Journal of Molecular Science ) 

    Figure 3 Research results (Source: International Journal of Molecular Science ) 

    Research findings include:

    Research findings include:

    1.
    Artificial sweeteners significantly disrupt the mechanism of action between intestinal bacteria (Escherichia coli and Enterococcus faecalis) and intestinal epithelial cells ; 

    1.
    Artificial sweeteners significantly disrupt the mechanism of action between intestinal bacteria (Escherichia coli and Enterococcus faecalis) and intestinal epithelial cells ; 

    2.
    Artificial sweeteners affect gut bacteria (Escherichia coli and Enterococcus faecalis) through taste perception mechanisms .
     

    2.


    Artificial sweeteners affect gut bacteria (Escherichia coli and Enterococcus faecalis) through taste perception mechanisms .


    This study shows that artificial sweeteners alter the gut microbiota through a taste-dependent pathway, making the otherwise harmless Escherichia coli and Enterococcus faecalis pathogenic to humans


    Looking at multiple studies, it has been shown that artificial sweeteners can cause certain harm to the human body, and may even cause disease.


    References:

    [1]Shil A, Chichger H.


    [1]Shil A, Chichger H.


    [2] Debras C, Chazelas E, Srour B, et al.
    Artificial sweeteners and cancer risk: Results from the NutriNet-Santé population-based cohort study.
    PLoS Med.
    2022 Mar 24;19(3):e1003950.
    doi: 10.
    1371 /journal.
    pmed.
    1003950.
    PMID: 35324894.
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