Summary and analysis of problems encountered in using Suzhou wet granulator

The problems encountered in the use of Suzhou wet granulator are explained in detail as follows: the control of mixing, granulation procedure and time sequence, the mastery of slurry concentration, the pouring of extract, the difference between alcohol granulation and paste refined granulation, and the debugging skills of centrifugal granulation masterbatch (I) control of mixing and granulating procedures and time sequence When the stirring paddle rotates, the materials in the pot roll in three-dimensional space At the same time, the materials are formed from the bottom of the pot and are thrown along the wall of the pot The wave peaks are exactly one after another, and the soft materials are pushed to the rapid cutting granulator At this time, the irregular shape of the soft materials are cut into different sizes of round angular particles After a period of time, the small particles are gradually rounded It is spherical From the above principle, we can adjust the speed and time of the two impellers to achieve the particle size In the pelletizer, we use the motor with double frequency conversion to control the movement of the two oars, and compile the program at the same time The purpose is to achieve the unity of batch and batch quality (2) to master the slurry concentration when using Suzhou wet granulator, whether using concentrated extract as slurry after dilution, or using dextrin or other adhesives as slurry, the concentration of slurry is generally thin when making small particles, and slightly thick when making large particles On the premise of not affecting the slurry transportation effect, the binder for heavy materials should be put less and the binder for light materials should be increased slightly (3) the experience of pouring the extract is that the viscosity of the traditional Chinese medicine extract is high and it cannot flow by itself If the extract slurry is directly poured into the mixing pot, it will cause that the extract slurry and auxiliary materials cannot be mixed evenly In addition, it will cause the granulation to agglomerate, that is to say, it can not be cut by using a high-speed granulating knife Because the thick extract is much harder than western medicine According to our debugging experience, a good way for Zui is to first use alcohol with a concentration of more than 95% to dilute the extract The diluted extract can flow by itself, and then put it into a sealed slurry adding container Through compressed air pressure, a porous nozzle is used to spray the diluted slurry evenly and rapidly to the material This time should be as short as possible, because traditional Chinese medicine is easy to absorb moisture Alcohol volatilizes very quickly, and the effect is better in one minute The whole granulation process should also be short, generally controlled within 2-5 minutes Of course, the physical properties of various materials will also be different, so the specific data should be adjusted in the process (IV) the difference between alcohol granulation and dextrin granulation Alcohol granulation is a common method, because the alcoholic body does not have viscosity, and it also plays a loose role, so the particles are relatively small and fine, the advantage of which is fast drying, and the effect of alcohol granulation for traditional Chinese medicine with high viscosity is ideal For example, dextrin is used to make granules, because dextrin has viscosity, it plays a role of polymerization, so the prepared granules are relatively large and coarse, the disadvantage of which is slow drying, and the effect of making granules with dextrin for western medicine without viscosity is better (V) production of masterbatch of centrifugal granulation many pharmaceutical factory users hope to use the wet granulator in Suzhou The particles made in the above process are used as the mother pellets in the centrifugal granulation of the next process As the dried particles after the wet granulation are in irregular round shape, it is suggested to add a rolling process, which can be carried out on the sugar coating machine During the rolling process, some water can be injected properly After this process, the roundness of the mother pellets is greatly improved, so the centrifugal granulation or coating treatment is more ideal.