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    Home > Biochemistry News > Biotechnology News > "Super transplant" could be effective in treating type 1 diabetes

    "Super transplant" could be effective in treating type 1 diabetes

    • Last Update: 2020-06-01
    • Source: Internet
    • Author: User
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    Diabetes has type 1 and type 2, of which type 1 diabetes is more of a human immune chronic disease, due to the damage of autoimmune-mediated pancreatic beta cells caused by the loss of their synthesis and secretion of insulin function, the patients are mainly children and adolescentsInsulin is the drug of choice for type 1 diabetesAt present, there are various types of short-acting, long-acting insulin drugs, as well as insulin pumps that regulate insulin release for clinical treatmentrecently, researchers at the University of Geneva and its hospitals in Switzerland proposed a "super-transplant" approach to treating diabetes by adding amniotic epithel cells (hAECs) to pancreatic cells to create a more robust new islet, which is a ray of light for all diabetics waiting for a transplantDOI:10.1038/s41467-019-12472-3the production of "super islet" can cure type 1 diabetes patients, but there are still donor deficiency, multiple transplantation, islet cell easily isolated purification difficultiesleft: a standard islet; right: a "super islet"insulin cell (beta cells) blue, glucagon cells (alpha cells) red; and super islet with amniotic epithelial cells (green)Fanny Lebreton, a surgical researcher at the University of Geneva, a researcher in surgery at the University of Geneva's School of Medicine, said the experiment was first conducted in vitro, adding hAECs to ICs and finding balls with rules for cell cluster formation, suggesting improved communication and connections within cellsislet-like organsthen carried out in vivo experiments, transplanted "super islet" into diabetic SCID mice, found that even if the cell cluster is small, "super islet" can adapt well to the new environment, and soon began to vascularizationGood vascularization is the key to any transplant, providing oxygen and nutrients to the new organs so that the artificial islet quickly begins to produce insulin, which works in diabetic micethe invivy function of islet-like organshAECsthe role of hAECs to protect the islet, there are two main important factors: one is to improve oxygenation, and the other is to regulate the host immune system to reduce rejectionResearcher Ekaterine Berishvili said hAECs have a "non-self" spirit that is worth celebrating, protecting the fetus from the mother's immune system, and speculate that applying hAECs to other types of transplants may have the same protective mechanism Thierry Berney, professor of surgery at the University of Geneva School of Medicine and director of transplantation at the University Hospital of Geneva, said hAECs are very similar to stem cells and are also being used in other treatments such as corneal repair In the "super islet" of this study, hAECs can promote the functioning of pancreatic cells based on fluctuations in sugar levels conclusion active insulin secretion organs consisting of hAECs and isolated ICs have been shown to have good efficacy in cell therapy models of type 1 diabetes, although the study has not yet been confirmed in human trials, but since hAECs have no side effects and are widely used in clinical practice, it is bold lying that "super islet" benefits patients within the day! This also offers new prospects for other types of transplants! References: DOI: 10.1038/s41467-019-12472-3
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