Supplementing NAD can save the reproductive capacity of aging women.

Title Translation: Supplementing NAD plus can save women's fertility during reproductive aging (document author) S Michael J. Bertoldo, Dave R. Listijono, Wing-Hong Jonathan Ho, David A. Sinclair, Hayden A. Homer, Lindsay E. Wu Published by Cell Reports 2020.2 Impact Factor 8.109 (Document Reading) As female fertility in mammals irreversibly declines with age, maternal age and subsequent infertility have become major challenges for family planning.
quality of ovarian cells determines whether a woman is able to successfully have a pregnancy.
women approach their 30s, the quality of ovarian cells decreases significantly.
but there is no clinically feasible way to maintain or restore the quality of ovarian cells during aging.
decline in the quality of ovarian cells has led to a demand for assisted reproductive technologies (ART) such as in-body fertilization in older pregnancies, but these technologies are health risky, expensive and have limited success rates.
non-invasive drug therapy that maintains or restores ovarian cell quality as we age can improve the success rate of these reproductive technologies in pregnancy.
ovarian cells in the ovaries are non-renewable and therefore prone to age-related dysfunction.
the molecular basis of decreased quality of ovarian cells with age included genomic instability, decreased mitochondrial bioenellis, and increased reactive oxygen (ROS).
: Images from the Network Niacinamide adenine dinucleotide (NAD plus) is an anti-aging substance.
is the decline in ovarian cell quality accompanied by a decline in NAD-plus levels, and can supplementation with NAD-pregeneral NMN restore ovarian cell quality to save fertility in older women? To answer these questions, the researchers used mice with ovarian cell defects similar to those found in humans, whose fertility began to decline at eight months of age.
12-month-old female mice were fed NMN drinking water (2 g / L) for 4 consecutive weeks, then mature mid-stage II (MII) ovary cells were recovered and microscopy was performed to determine their relative abundance.
found that NAD (P)H levels decreased in ovarian cells in older animals compared to younger (4 to 5 weeks) animals, while NMN treatment increased NAD (P) H levels in ovarian cells in older animals.
Then, to test whether a drop in ovarian levels would alter the quality of ovarian cells, the researchers fed 14-month-old female mice drinking water containing NMN (2 g/L) for four weeks and set up a blank control group without NMN.
collected reproductive blister (GV) stage ovary cells to assess the effect of the intervention on ovarian cell quality, it was found that NMN therapy significantly improved the quality of ovarian cells in elderly female mice.
( Literature Summary ) Treatment with NAD plus metabolic prelubid nicotinamide mononucleotides (NMN) can improve the quality of ovarian cells in aging animals and restore vitality, leading to fertility recovery, at which point supplementary nutrition can reverse the adverse effects of maternal age on reproduction.
findings suggest that late recovery at the NAD plus level provides an opportunity to save female reproductive function in mammals.
, the study is still in clinical trials, despite the bright future.
researchers should look at testing NAD plus in a clinical setting to assess the relationship between these findings and human infertility.
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: Ovarian cells: ovogen cells that are subtracted during egg occurrence.
are divided into primary obstetric cells, secondary ovary cells and mature ovary cells, which are the product of ovogen cell differentiation and DNA replication division, first de-division and second-detracted division, respectively.
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