Surface dynamics controlled preparation of mesoporous polypods for high efficiency bacterial adhesion and inhibition

Human beings have always been learning from nature, especially in material preparation In nature, from viruses to Tribulus terrestris and Xanthium sibiricum, all show to human beings on different scales: the multi foot structure can effectively improve the interface between the host and guest through multi-point contact In the field of nanomaterials, the force between nanoparticles and biomass plays an important role in applications such as intracellular drug delivery, bacteriostasis and so on This force is closely related to the surface structure of nanomaterials Because of the multi foot structure of Tribulus terrestris seeds and virus, if the nano particles with multi foot structure can be synthesized, and the multi point contact effect can be used to strengthen the interaction between Nano biological interface, the adhesion and penetration ability of nano particles to biomass will be improved, and the application effect will also be improved However, due to the limitation of synthesis technology, there is still a lack of reports on the multi legged nanostructures A few work is also based on nanocrystalline, polymer and other materials The nanoparticles lack enough drug loading capacity, so it is difficult to apply to drug delivery, sterilization and other applications Li Xiaomin, a young researcher in the Department of chemistry of Fudan University and Zhao Dongyuan, a team of academicians, have explored the anisotropic nucleation and growth of mesoporous materials at a unit point in their previous work, and prepared a series of new anisotropic nanoparticles based on this However, in these works, only one mesoporous "foot" can be produced by unit point nucleation If we want to prepare mesoporous multi legged nanoparticles to improve the interaction between Nano and biological forces, the number of nucleation sites on the surface of nanoparticles must be precisely controlled Recently, based on the previous work, the research team has further developed the multi-point nucleation strategy controlled by surface dynamics, and prepared mesoporous and multi legged nanocomposites with controllable surface structure By adjusting the surface chemical properties of Fe3O4 @ SiO2 @ RF (RF = resorcinol formaldehyde resin) nanoparticles, PMO (periodic mesoporous) was realized In order to control the number of nucleation sites, a series of mesoporous and multi legged composites with controllable surface structure were prepared: Janus, bipedal, tripod, quadruped, and multi legged Just as Tribulus terrestris and Xanthium sibiricum are attached to animals through multi foot structure, this kind of multi foot structure also endows mesoporous nanocomposites with excellent bacterial adhesion ability With the help of strong nano biological interaction provided by tribulus like quadruped structure and the drug loading ability given by mesoporous channels, the Tribulus like quadruped mesoporous nanocomposites show high-efficiency bacterial adhesion, nearly 100% bacterial separation efficiency and more than 90% long-term bacterial killing ability In conclusion, this work is expected to provide more ideas for the future design of complex nano particle surface structure and enhanced nano biological interaction Relevant papers were recently published in nature communications (DOI: 10.1038 / s41467-019-12378-0) The first author of the paper is Zhao Tiancong, a doctoral student, Li Xiaomin, a young researcher, and Zhao Dongyuan, a professor, as the co authors of the paper This work has been greatly supported by the Department of chemistry, advanced materials laboratory, Shanghai Science and Technology Commission, and National Natural Science Foundation of Fudan University.