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    Home > Biochemistry News > Biotechnology News > Surface Plasmon Resonance for Proteomics

    Surface Plasmon Resonance for Proteomics

    • Last Update: 2020-12-01
    • Source: Internet
    • Author: User
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    Surface plasmon resonance (SPR) is a well-established label-free technique to detect mass changes near an SPR surface. For20 years the benefits of SPR have been proven in biomolecular interaction analysis, including measurements of affinity andkinetics. The emergence of proteomics and a need for high throughput analysis drives the development of SPR systems capableof analyzing microarrays. The use of SPR imaging (also known as SPR microscopy) makes it possible to use multiplexed arraysto follow binding reactions. As SPR only analyzes the binding process, but not the identity of captured molecules on the SPRsurface, technologies have been developed to integrate SPR with mass spectrometric (MS) analysis. Such approaches involvethe recovery of analytes from the SPR surface and subsequent MALDI-TOF MS analysis, or LC-MS/MS after tryptic digestion ofrecovered proteins. An approach compatible with SPR arrays is on-chip MALDI-TOF MS, from arrayed spots on an SPR surface. This review describes some exciting developments in the application of SPR to proteomics, using instruments which are on themarket already, or are expected to be available in the years to come.
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