Surg Endosc: Effect of iralazole on gastric ulcer healing caused by sublime sublime peeling under the endoscopy
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Last Update: 2020-07-10
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Source: Internet
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Author: User
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The best treatment option or duration of treatment for gastric ulcers induced by endoscopic sub-mucosal peeling (ESD) has not yet been determinedThe purpose of this study is to evaluate the efficacy of the new proton pump inhibitor iprazole (irapazol) in the treatment of ESD-induced stomach ulcersa forward-looking, open-label, randomized multicenter study designed between June 2015 and March 2018, a total of 176 patients receiving ESD for gastric tumors (178 lesions) were randomly assigned to receive oral proton pump inhibitor iralaprazor20 mg or rabeprazole 20 mg for 8 weeks of daily treatmentThe main outcome is the ulcer healing rate in weeks 4 and 8results showed that improved intentional therapy (mITT) and programme-by-programme analysis included 155 cases (157 lesions) and 154 patients (156 lesions), respectivelyUlcer healing rates between treatment groups (auraanda and rebella, 97.4% and 97.0 at 4 weeks, p - 0.78; 100% vs100%, p - 0.95) or ulcer phases (in mITT analysis, scar stages, 25.6% and 17.7% at 4 weeks, p - 0.25; 88.6%, p s 0.59) No significant differenceThere was no significant difference in the healing quality of ulcers in the two groupsIn the multivariate analysis, no independent predictors of high-quality ulcer healing were foundin general, there was no significant difference in the healing of artificial stomach ulcers between Alarazole and RebellaazoleMost ulcers are completely cured within 4 to 8 weeks
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