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    Home > Active Ingredient News > Digestive System Information > Surg Endosc: Effect of iralazole on gastric ulcer healing caused by sublime sublime peeling under the endoscopy

    Surg Endosc: Effect of iralazole on gastric ulcer healing caused by sublime sublime peeling under the endoscopy

    • Last Update: 2020-07-10
    • Source: Internet
    • Author: User
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    The best treatment option or duration of treatment for gastric ulcers induced by endoscopic sub-mucosal peeling (ESD) has not yet been determined

    The purpose of this study is to evaluate the efficacy of the new proton pump inhibitor iprazole (irapazol) in the treatment of ESD-induced stomach ulcers







    a forward-looking, open-label, randomized multicenter study designed between June 2015 and March 2018, a total of 176 patients receiving ESD for gastric tumors (178 lesions) were randomly assigned to receive oral proton pump inhibitor iralaprazor20 mg or rabeprazole 20 mg for 8 weeks of daily treatment

    The main outcome is the ulcer healing rate in weeks 4 and 8







    results showed that improved intentional therapy (mITT) and programme-by-programme analysis included 155 cases (157 lesions) and 154 patients (156 lesions), respectively

    Ulcer healing rates between treatment groups (auraanda and rebella, 97.4% and 97.0 at 4 weeks, p - 0.78; 100% vs

    100%, p - 0.95) or ulcer phases (in mITT analysis, scar stages, 25.6% and 17.7% at 4 weeks, p - 0.25; 88.6%, p s 0.59) No significant difference

    There was no significant difference in the healing quality of ulcers in the two groups

    In the multivariate analysis, no independent predictors of high-quality ulcer healing were found







    in general, there was no significant difference in the healing of artificial stomach ulcers between Alarazole and Rebellaazole

    Most ulcers are completely cured within 4 to 8 weeks







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