Synthesis of AApeptides
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Last Update: 2021-03-02
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Source: Internet
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Author: User
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The creation and development of nonnatural peptidomimetics has become an area of increasing significance in bioorganic andchemical biology. A wide range of new peptide mimics with novel structures and functions are urgently needed to be exploredin order to identify potential drug candidates and targeted probes, and to study protein functions. AApeptides are a new classof peptide mimics based on chiral PNA backbone. They are resistant to proteolytic degradation and have limitless potentialfor diversification. They have been found to have a wide variety of biological applications including cellular translocation,disruption of protein–protein interactions, formation of nanostructures, antimicrobial activity, etc. The synthesis of AApeptidesis modular and straightforward. In this chapter, methods for the synthesis of AApeptides (including different subclasses)are described.
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