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    Home > Biochemistry News > Biotechnology News > Synthesis of DNA Mimics Representing HypNA-pPNA Hetero-Oligomers

    Synthesis of DNA Mimics Representing HypNA-pPNA Hetero-Oligomers

    • Last Update: 2021-03-06
    • Source: Internet
    • Author: User
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    The methods for the synthesis and purification of negatively charged peptide nucleic acid (PNA)-relative deoxyribonucleic acid (
    DNA
    ) mimics containing alternating residues of phosphono peptide nucleic acid (pPNA) monomers and PNA-like monomers on the base of
    trans
    -4-hydroxy-
    L-proline are described. Examples of the chimeric oligomers hybridization with complementary DNA and ribonucleic acid fragments are demonstrated.
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