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Phospholipids and cholesterol are the lipid component of cellular and subcellular membranes and are transported primarily (>65%) in low-density lipoproteins (
1
). The fatty acids of these compounds are easily attacked by reactive oxygen species leading to the formation of their respective peroxides (
2
–
4
). Cholesterol can be oxidized directly with hydroperoxide formation at the 5, 7, and 25 positions (
5
). The ratio of oxidized phospholipid to cholesterol markedly increases membrane fluidity and deformability characteristics (
6
).